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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 15, Iss. 17 — Aug. 20, 2007
  • pp: 10911–10919

Effect of speckles on the depth sensitivity of laser Doppler perfusion imaging

V. Rajan, B. Varghese, T. G. van Leeuwen, and W. Steenbergen  »View Author Affiliations


Optics Express, Vol. 15, Issue 17, pp. 10911-10919 (2007)
http://dx.doi.org/10.1364/OE.15.010911


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Abstract

A theoretical model is presented and experimentally validated that allows the prediction of the effect of speckles on the depth sensitivity of laser Doppler perfusion imaging. It is shown that the influence of speckles on depth sensitivity is large. In particular the sensitivity to particle motion in superficial layers is strongly beam diameter dependent: decreasing the beam diameter on the tissue surface increases the sensitivity to superficial motion to a much stronger extent than sensitivity to motion at a larger depth. This can be explained through the effect of beam diameter changes on the fractional coherence areas generated by photons with different penetration depths in the tissue.

© 2007 Optical Society of America

OCIS Codes
(170.1650) Medical optics and biotechnology : Coherence imaging
(170.3340) Medical optics and biotechnology : Laser Doppler velocimetry
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(290.1350) Scattering : Backscattering

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: June 11, 2007
Revised Manuscript: August 9, 2007
Manuscript Accepted: August 13, 2007
Published: August 15, 2007

Virtual Issues
Vol. 2, Iss. 9 Virtual Journal for Biomedical Optics

Citation
V. Rajan, B. Varghese, T. G. van Leeuwen, and W. Steenbergen, "Effect of speckles on the depth sensitivity of laser Doppler perfusion imaging," Opt. Express 15, 10911-10919 (2007)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-15-17-10911


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References

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