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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 15, Iss. 19 — Sep. 17, 2007
  • pp: 11874–11882

Optics InfoBase > Optics Express > Volume 15 > Issue 19 > Page 11874

Development of a handheld Raman microspectrometer for clinical dermatologic applications

Chad Lieber and Anita Mahadevan-Jansen  »View Author Affiliations


Optics Express, Vol. 15, Issue 19, pp. 11874-11882 (2007)
http://dx.doi.org/10.1364/OE.15.011874


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Abstract

Although skin is easily accessible to optical methodologies, a portable measurement head is necessary to allow ready spectroscopic interrogation of all anatomic locations. However, most conventional Raman microspectrometers and even dermatologic-specific Raman systems are fixed systems ill-suited to anatomic accessibility. To this end, we have developed a portable Raman microspectrometer system for future dermatologic studies. An in-house-built bench-top system was used to qualify the optical components and design. Based on this system’s layout, a handheld microspectrometer was developed for future clinical application. This system produces similar operating characteristics to the bench-top prototype, and is shown to provide clear Raman spectra from skin tissue measured in vivo in clinically-feasible integration times.

© 2007 Optical Society of America

OCIS Codes
(120.3890) Instrumentation, measurement, and metrology : Medical optics instrumentation
(170.1870) Medical optics and biotechnology : Dermatology
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(300.6450) Spectroscopy : Spectroscopy, Raman

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: June 11, 2007
Revised Manuscript: August 16, 2007
Manuscript Accepted: August 25, 2007
Published: September 4, 2007

Virtual Issues
Vol. 2, Iss. 10 Virtual Journal for Biomedical Optics

Citation
Chad Lieber and Anita Mahadevan-Jansen, "Development of a handheld Raman microspectrometer for clinical dermatologic applications," Opt. Express 15, 11874-11882 (2007)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-15-19-11874


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