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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 15, Iss. 19 — Sep. 17, 2007
  • pp: 12277–12285

Initial results of in vivo non-invasive cancer imaging in the human breast using near-infrared photoacoustics

Srirang Manohar, Susanne E. Vaartjes, Johan C. G. van Hespen, Joost M. Klaase, Frank M. van den Engh, Wiendelt Steenbergen, and Ton G. van Leeuwen  »View Author Affiliations


Optics Express, Vol. 15, Issue 19, pp. 12277-12285 (2007)
http://dx.doi.org/10.1364/OE.15.012277


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Abstract

Near-infrared photoacoustic images of regions-of-interest in 4 of the 5 cases of patients with symptomatic breasts reveal higher intensity regions which we attribute to vascular distribution associated with cancer. Of the 2 cases presented here, one is especially significant where benign indicators dominate in conventional radiological images, while photoacoustic images reveal vascular features suggestive of malignancy, which is corroborated by histopathology. The results show that photoacoustic imaging may have potential in visualizing certain breast cancers based on intrinsic optical absorption contrast. A future role for the approach could be in supplementing conventional breast imaging to assist detection and/or diagnosis.

© 2007 Optical Society of America

OCIS Codes
(170.1610) Medical optics and biotechnology : Clinical applications
(170.3830) Medical optics and biotechnology : Mammography
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5120) Medical optics and biotechnology : Photoacoustic imaging
(170.7170) Medical optics and biotechnology : Ultrasound

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: July 25, 2007
Revised Manuscript: September 3, 2007
Manuscript Accepted: September 10, 2007
Published: September 12, 2007

Virtual Issues
Vol. 2, Iss. 10 Virtual Journal for Biomedical Optics

Citation
Srirang Manohar, Susanne E. Vaartjes, Johan C. G. van Hespen, Joost M. Klaase, Frank M. van den Engh, Wiendelt Steenbergen, and Ton G. van Leeuwen, "Initial results of in vivo non-invasive cancer imaging in the human breast using near-infrared photoacoustics," Opt. Express 15, 12277-12285 (2007)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-15-19-12277


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References

  1. D. M. Parkin, F. Bray, J. Ferlay and P. Pisani, "Global Cancer Statistics, 2002," C. A. Cancer J. Clin. 55, 74-108 (2005). [CrossRef]
  2. S. J. Nass, I. C. Henderson and J. C. Lashof, Mammography and Beyond: Developing Technologies for the Early Detection of Breast Cancer (National Academy Press, 2001).
  3. M. A. Franceschini, K. T. Moesta, S. Fantini, G. Gaida, E. Gratton, H. Jess, W. W. Mantulin, M. Seeber, P. M. Schlag and M. Kaschke, "Frequency-domain techniques enhance optical mammography: Initial clinical results," PNAS 94, 6468-6473 (1997). [CrossRef] [PubMed]
  4. D. Grosenick, H. Wabnitz, H. H. Rinneberg, K. T. Moesta and P. M. Schlag, "Development of a time domain optical mammograph and first in vivo applications," Appl. Opt. 38, 2927-2943 (1999). [CrossRef]
  5. P. Carmeliet and R. K. Jain, "Angiogenesis in cancer and other diseases," Nature 407, 249-257 (2000). [CrossRef] [PubMed]
  6. P. Vaupel, F. Kallinowski and P. Okunieff, "Blood Flow, Oxygen and Nutrient Supply, and Metabolic Microenvironment of Human Tumors: A Review," Cancer Res. 49, 6449-6465 (1989). [PubMed]
  7. B. J. Tromberg, N. Shah, R. Lanning, A. Cerussi, J. Espinoza, T. Pham, L. Svaasand and J. Butler, "Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy," Neoplasia 2, 26-40 (2000). [CrossRef] [PubMed]
  8. B. W. Pogue, S. P. Poplack, T. O. McBride, W. A. Wells, K. S. Osterman, U. L. Osterberg and K. D. Paulsen, "Quantitative Hemoglobin Tomography with Diffuse Near-Infrared Spectroscopy: Pilot Results in the Breast," Radiology 218, 261-266 (2001). [PubMed]
  9. M. Xu and L. V. Wang, "Photoacoustic imaging in biomedicine," Rev. Sci. Instrum. 77, 041101 (2006). [CrossRef]
  10. A. A. Oraevsky, E. V. Savateeva, S. V. Solomatin, A. A. Karabutov, V. G. Andreev, Z. Gatalica, T. Khamapirad and P. M. Henrichs, "Optoacoustic imaging of blood for visualization and diagnostics of breast cancer," Proc. SPIE 4618, 81-94 (2002). [CrossRef]
  11. T. Khamapirad, P. M. Henrichs, K. Mehta, T. G. Miller, A. T. Yee and A. A. Oraevsky, "Diagnostic imaging of breast cancer with LOIS: clinical feasibility," Proc. SPIE 5697, 35-44 (2005). [CrossRef]
  12. R. A. Kruger, K. D. Miller, H. E. Reynolds, W. L. KiserJr., D. R. Reinecke, G. A. Kruger, "Breast Cancer in vivo: Contrast Enhancement with Thermoacoustic CT at 434 MHz-Feasibility Study," Radiology 216, 279-283 (2000). [PubMed]
  13. S. Manohar, A. Kharine, J. C. G. van Hespen, W. Steenbergen and T. G. van Leeuwen, "The Twente Photoacoustic Mammoscope: system overview and performance," Phys. Med. Biol. 502543-2557 (2005). [CrossRef] [PubMed]
  14. S. Manohar, A. Kharine, J. C. G. van Hespen, W. Steenbergen and T. G. van Leeuwen, "Photoacoustic mammography laboratory prototype: imaging of breast tissue phantoms," J. Biomed. Opt. 9, 1172-1181 (2004). [CrossRef] [PubMed]
  15. F. A. Duck, Physical Properties of Tissue (Academic Press, 1990).
  16. L. Spinelli, A. Torricelli, A. Pifferi, P. Taroni, G. M. Danesini and R. Cubeddu, "Bulk optical properties and tissue components in the female breast from multiwavelength time-resolved optical mammography," J. Biomed. Opt. 9, 1137-1142 (2004). [CrossRef] [PubMed]
  17. T. P. Padera, B. R. Stoll, J. B. Tooredman, D. Capen, E. Di Tomaso and R. K. Jain, "Cancer cells compress intratumour vessels," Nature 427, 695 (2004). [CrossRef] [PubMed]
  18. M. Sarntinoranont, F. Rooney and M. Ferrari, "Interstitial stress and fluid pressure within a growing tumor," Ann. Biomed. Eng. 31, 327-335 (2003). [CrossRef] [PubMed]
  19. J. Holash, P. C. Maisonpierre, D. Compton, P. Boland, C. R. Alexander, D. Zagzag. G. D. Yancopoulos and S. J. Wiegand, "Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF," Science 284, 1994-1998 (1999). [CrossRef] [PubMed]
  20. G. D. Yancopoulos, S. Davis, N. W. Gale, J. S. Rudge, S. J. Wiegand and J. Holash, "Vascular-specific growth factors and blood vessel formation," Nature 407, 242-248 (2000). [CrossRef] [PubMed]
  21. R. Matsubayashi, Y. Matsuo, G. Edakuni, T. Satoh, O. Tokunaga and S. Kudo, "Breast Masses with Peripheral Rim Enhancement on Dynamic Contrast-enhanced MR Images: Correlation of MR Findings with Histologic Features and Expression of Growth Factors," Radiology 217, 841-848 (2000). [PubMed]
  22. J. Laufer, D. Delpy, C. Elwell and P. Beard, "Quantitative spatially resolved measurement of tissue chromophore concentrations using photoacoustic spectroscopy:application to the measurement of blood oxygenation and haemoglobin concentration," Phys. Med. Biol. 52, 141-168 (2007). [CrossRef]

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