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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 15, Iss. 2 — Jan. 22, 2007
  • pp: 408–422

Resonant Doppler flow imaging and optical vivisection of retinal blood vessels

Adrian H. Bachmann, Martin L. Villiger, Cedric Blatter, Theo Lasser, and Rainer A. Leitgeb  »View Author Affiliations

Optics Express, Vol. 15, Issue 2, pp. 408-422 (2007)

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For Fourier domain optical coherence tomography any sample movement during camera integration causes blurring of interference fringes and as such reduction of sensitivity for flow detection. The proposed method overcomes this problem by phase-matching a reference signal to the sample motion. The interference fringes corresponding to flow signal will appear frozen across the detector whereas those of static sample structures will be blurred resulting in enhanced contrast for blood vessels. An electro-optic phase modulator in the reference arm, driven with specific phase cycles locked to the detection frequency, allows not only for qualitative but also for quantitative flow detection already from the relative signal intensities. First applications to extract in-vivo retinal flow and to visualize 3D vascularization, i.e. optical vivisection, are presented.

© 2007 Optical Society of America

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(110.6880) Imaging systems : Three-dimensional image acquisition
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4470) Medical optics and biotechnology : Ophthalmology
(170.4500) Medical optics and biotechnology : Optical coherence tomography

ToC Category:
Imaging Systems

Original Manuscript: October 27, 2006
Revised Manuscript: December 21, 2006
Manuscript Accepted: January 2, 2007
Published: January 22, 2007

Virtual Issues
Vol. 2, Iss. 2 Virtual Journal for Biomedical Optics

Adrian H. Bachmann, Martin L. Villiger, Cedric Blatter, Theo Lasser, and Rainer A. Leitgeb, "Resonant Doppler flow imaging and optical vivisection of retinal blood vessels," Opt. Express 15, 408-422 (2007)

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