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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 15, Iss. 2 — Jan. 22, 2007
  • pp: 754–759

Damage of supercoiled DNA by an ultrafast laser-driven electron x-ray source

Fang Shan, Joshua D. Carter, and Ting Guo  »View Author Affiliations

Optics Express, Vol. 15, Issue 2, pp. 754-759 (2007)

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Using magnetic fields to differentiate the effects of electrons and x-rays, it was discovered that single strand breaks in supercoiled DNA were mainly caused by the energetic ultrafast electrons rather than the ultrafast x-ray photons emitted from the same table-top ultrafast x-ray source. At constant pulse energy of the driving laser pulses, shorter laser pulses produced more strand breaks than longer ones. This was attributed to the increased flux of electrons produced with the shorter laser pulses. Other factors contributing to the DNA damage were investigated and discussed.

© 2007 Optical Society of America

OCIS Codes
(170.7160) Medical optics and biotechnology : Ultrafast technology
(320.7120) Ultrafast optics : Ultrafast phenomena
(350.5610) Other areas of optics : Radiation

ToC Category:
Ultrafast Optics

Original Manuscript: October 6, 2006
Revised Manuscript: December 19, 2006
Manuscript Accepted: January 12, 2007
Published: January 22, 2007

Virtual Issues
Vol. 2, Iss. 2 Virtual Journal for Biomedical Optics

Fang Shan, Joshua D. Carter, and Ting Guo, "Damage of supercoiled DNA by an ultrafast laser-driven electron x-ray source," Opt. Express 15, 754-759 (2007)

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