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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 15, Iss. 23 — Nov. 12, 2007
  • pp: 15193–15206

Automatic retinal blood flow calculation using spectral domain optical coherence tomography

Hassan Wehbe, Marco Ruggeri, Shuliang Jiao, Giovanni Gregori, Carmen A. Puliafito, and Weizhao Zhao  »View Author Affiliations


Optics Express, Vol. 15, Issue 23, pp. 15193-15206 (2007)
http://dx.doi.org/10.1364/OE.15.015193


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Abstract

Optical Doppler tomography (ODT) is a branch of optical coherence tomography (OCT) that can measure the speed of a blood flow by measuring the Doppler shift impinged on the probing sample light by the moving blood cells. However, the measured speed of blood flow is a function of the Doppler angle, which needs to be determined in order to calculate the absolute velocity of the blood flow inside a vessel. We developed a technique that can extract the Doppler angle from the 3D data measured with spectral-domain OCT, which needs to extract the lateral and depth coordinates of a vessel in each measured ODT and OCT image. The lateral coordinates and the diameter of a blood vessel were first extracted in each OCT structural image by using the technique of blood vessel shadowgram, a technique first developed by us for enhancing the retinal blood vessel contrast in the en face view of the 3D OCT. The depth coordinate of a vessel was then determined by using a circular averaging filter moving in the depth direction along the axis passing through the vessel center in the ODT image. The Doppler angle was then calculated from the extracted coordinates of the blood vessel. The technique was applied in blood flow measurements in retinal blood vessels, which has potential impact on the study and diagnosis of blinding diseases like glaucoma.

© 2007 Optical Society of America

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(120.3890) Instrumentation, measurement, and metrology : Medical optics instrumentation
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine

ToC Category:
Imaging Systems

History
Original Manuscript: July 9, 2007
Revised Manuscript: October 9, 2007
Manuscript Accepted: October 25, 2007
Published: November 1, 2007

Virtual Issues
Vol. 2, Iss. 12 Virtual Journal for Biomedical Optics

Citation
Hassan Wehbe, Marco Ruggeri, Shuliang Jiao, Giovanni Gregori, Carmen A. Puliafito, and Weizhao Zhao, "Automatic retinal blood flow calculation using spectral domain optical coherence tomography," Opt. Express 15, 15193-15206 (2007)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-15-23-15193


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