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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 15, Iss. 23 — Nov. 12, 2007
  • pp: 15507–15516

Hemodynamic responses to antivascular therapy and ionizing radiation assessed by diffuse optical spectroscopies

Ulas Sunar, Sosina Makonnen, Chao Zhou, Turgut Durduran, Guoqiang Yu, Hsing-Wen Wang, William M. F. Lee, and Arjun G. Yodh  »View Author Affiliations


Optics Express, Vol. 15, Issue 23, pp. 15507-15516 (2007)
http://dx.doi.org/10.1364/OE.15.015507


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Abstract

Diffuse optical methods were used to monitor two different therapies in K1735 malignant mouse melanoma tumor models: anti-vascular therapy and radiation therapy. Anti-vascular therapy induced acute variation in hemodynamic parameters within an hour, and radiation therapy induced longitudinal changes within 2 weeks. During anti-vascular therapy, the drug Combretastatin A-4 3-O-Phosphate (CA4P, 2.5 mg/200 μl PBS/mouse) significantly decreased tissue blood flow (65%) and blood oxygenation (38%) one hour after injection. In the longitudinal study, single-fraction ionizing radiation (12 Gy x 1) induced significant reduction of tissue blood flow (36%) and blood oxygenation (24%) 14 days after radiation. The results correlated well with contrast enhanced ultrasound, tumor histology, and a nitroimidazole hypoxia marker (EF5). The research provides further evidence that noninvasive diffuse optical spectroscopies can be useful tools for monitoring cancer therapy in vivo.

© 2007 Optical Society of America

OCIS Codes
(170.0110) Medical optics and biotechnology : Imaging systems
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6480) Medical optics and biotechnology : Spectroscopy, speckle

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: September 6, 2007
Revised Manuscript: October 26, 2007
Manuscript Accepted: October 29, 2007
Published: November 8, 2007

Virtual Issues
Vol. 2, Iss. 12 Virtual Journal for Biomedical Optics

Citation
Ulas Sunar, Sosina Makonnen, Chao Zhou, Turgut Durduran, Guoqiang Yu, Hsing-Wen Wang, William M. Lee, and Arjun G. Yodh, "Hemodynamic responses to antivascular therapy and ionizing radiation assessed by diffuse optical spectroscopies," Opt. Express 15, 15507-15516 (2007)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-15-23-15507


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