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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 15, Iss. 24 — Nov. 26, 2007
  • pp: 15854–15862

Invariant resolution dynamic focus OCM based on liquid crystal lens

S. Murali, K. S. Lee, and J. P Rolland  »View Author Affiliations

Optics Express, Vol. 15, Issue 24, pp. 15854-15862 (2007)

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A primary limitation of optical coherence microscopy is the lack of sufficient lateral resolution over a usable imaging volume for diagnostic applications, even with high-numerical aperture imaging optics. In this paper, we first motivate the benefit of refocusing at multiple depths in a highly scattering biological sample using optical coherence microscopy, which experimentally shows invariant 2.5 µm axial and 6.5 µm lateral resolution throughout the sample. We then present the optical system design of a hand-held probe with the advanced capability to dynamically focus with no moving parts to a depth of 2 mm in skin-equivalent tissue at 3 µm resolution throughout an 8 cubic millimeter imaging volume. The built-in dynamic focusing ability is investigated with an addressable liquid crystal lens embedded in a custom-designed optics optimized for a Ti:Sa pulsed broadband laser source of bandwidth 100nm centered at 800nm. The design was developed not only to account for refocusing into the tissue but also to minimize and compensate for the varying on-axis and off-axis optical aberrations that would be introduced throughout a 2 mm thick and 2 mm wide skin imaging volume. The MTF contrast functions and distortion plots at three different skin depths are presented.

© 2007 Optical Society of America

OCIS Codes
(080.3620) Geometric optics : Lens system design
(110.4500) Imaging systems : Optical coherence tomography
(120.3620) Instrumentation, measurement, and metrology : Lens system design
(120.3890) Instrumentation, measurement, and metrology : Medical optics instrumentation
(120.4570) Instrumentation, measurement, and metrology : Optical design of instruments
(170.3880) Medical optics and biotechnology : Medical and biological imaging

ToC Category:
Imaging Systems

Original Manuscript: October 5, 2007
Revised Manuscript: November 8, 2007
Manuscript Accepted: November 8, 2007
Published: November 15, 2007

Virtual Issues
Vol. 2, Iss. 12 Virtual Journal for Biomedical Optics

S. Murali, K. S. Lee, and J. P. Rolland, "Invariant resolution dynamic focus OCM based on liquid crystal lens," Opt. Express 15, 15854-15862 (2007)

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