OSA's Digital Library

Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 15, Iss. 24 — Nov. 26, 2007
  • pp: 16261–16269

In vivo monitoring of blood oxygenation in large veins with a triple-wavelength optoacoustic system

H. P. Brecht, D. S. Prough, Y. Y. Petrov, I. Patrikeev, I. Y. Petrova, D. J. Deyo, I. Cicenaite, and R. O. Esenaliev  »View Author Affiliations

Optics Express, Vol. 15, Issue 24, pp. 16261-16269 (2007)

View Full Text Article

Enhanced HTML    Acrobat PDF (149 KB)

Browse Journals / Lookup Meetings

Browse by Journal and Year


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools



A noninvasive optoacoustic technique could be a clinically useful alternative to existing, invasive methods for cerebral oxygenation monitoring. Recently we proposed to use an optoacoustic technique for monitoring cerebral blood oxygenation by probing large cerebral and neck veins including the superior sagittal sinus and the internal jugular vein. In these studies we used a multi-wavelength optoacoustic system with a nanosecond optical parametric oscillator as a light source and a custom-made optoacoustic probe for the measurement of the optoacoustic signals in vivo from the area of the sheep neck overlying the external jugular vein, which is similar in diameter and depth to the human internal jugular vein. Optoacoustic signals induced in venous blood were measured with high resolution despite the presence of a thick layer of tissues (up to 10 mm) between the external jugular vein and the optoacoustic probe. Three wavelengths were chosen to provide accurate and stable measurements of blood oxygenation: signals at 700 nm and 1064 nm demonstrated high correlation with actual oxygenation measured invasively with CO-Oximeter (“gold standard”), while the signal at 800 nm (isosbestic point) was independent of blood oxygenation and was used for calibration.

© 2007 Optical Society of America

OCIS Codes
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.5120) Medical optics and biotechnology : Photoacoustic imaging
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: August 13, 2007
Revised Manuscript: October 16, 2007
Manuscript Accepted: October 22, 2007
Published: November 21, 2007

Virtual Issues
Vol. 2, Iss. 12 Virtual Journal for Biomedical Optics

H. P. Brecht, D. S. Prough, Y. Y. Petrov, I. Patrikeev, I. Y. Petrova, D. J. Deyo, I. Cicenaite, and R. O. Esenaliev, "In vivo monitoring of blood oxygenation in large veins with a triple-wavelength optoacoustic system," Opt. Express 15, 16261-16269 (2007)

Sort:  Year  |  Journal  |  Reset  


  1. J. A. Langlois and R. W. Sattin, "Traumatic brain injury in the United States: Research and programs of the Centers for Disease Control and Prevention (CDC) - Preface," J. Head Trauma Rehab. 20,187-188 (2005). [CrossRef]
  2. W. Stevens, "Multimodal monitoring: head injury management using SjvO2 and LICOX," J. Neurosci Nurs. 36,332-339 (2004). [CrossRef]
  3. P. R. Smythe and S. K. Samra, "Monitors of cerebral oxygenation," Anes. Clin. N. Am. 20,293-313 (2002). [CrossRef]
  4. A. K. Gupta, "Monitoring the injured brain in the intensive care unit," J. Postgrad. Med. 48,218-225 (2002). [PubMed]
  5. S. Wray, M. Cope, D.T. Deply, J.S. Wyatt, and E.O.R. Reynolds. "Characterization of the near infrared absorption spectra of cytochrome aa3 and hemoglobin for the non-invasive monitoring of cerebral oxygenation," Biochem. et Biophys. Acta 933, 184-192 (1988). [CrossRef]
  6. A. Roggan, M. Friebel, K. Dorschel, A. Hahn, and G. Muller, "Optical properties of circulating human blood in the wavelength range 400-2500 nm," J. Biomed. Opt. 4,36-46 (1999). [CrossRef]
  7. A. G. Bell, "On the Production and Reproduction of Sound by Light: the Photophone," Am. J. Sci. 3,305-324 (1880).
  8. R. O. Esenaliev, I. V. Larina, K. V. Larin, D. J. Deyo, M. Motamedi, and D. S. Prough, "Optoacoustic technique for noninvasive monitoring of blood oxygenation: a feasibility study," Appl. Opt. 41,4722-4731 (2002). [CrossRef] [PubMed]
  9. J. A. Copland, M. Eghtedari, V. L. Popov, N. Kotov, N. Mamedova, M. Motamedi, and A. A. Oraevsky, "Bioconjugated gold nanoparticles as a molecular based contrast agent: Implications for imaging of deep tumors using optoacoustic tomography," Mol. Imaging Biol. 6,341-349 (2004). [CrossRef] [PubMed]
  10. M. Eghtedari, M. Motamedi, V. L. Popov, N. A. Kotov, and A. A. Oraevsky, "Optoacoustic imaging of gold nanoparticles targeted to breast cancer cells," Proc. SPIE 5320,21-28 (2004). [CrossRef]
  11. J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, "Combined ultrasound and optoacoustic system for real-time high-contrast vascular imaging in vivo," IEEE Trans. Med. Imaging 24,436-440 (2005). [CrossRef] [PubMed]
  12. X. D. Wang, Y. J. Pang, G. Ku, G. Stoica, and L. H. V. Wang, "Three-dimensional laser-induced photoacoustic tomography of mouse brain with the skin and skull intact," Opt. Lett. 28,1739-1741 (2003). [CrossRef] [PubMed]
  13. J. A. Viator, G. Au, G. Paltauf, S. L. Jacques, S. A. Prahl, H. W. Ren, Z. P. Chen, and J. S. Nelson, "Clinical testing of a photoacoustic probe for port wine stain depth determination," Laser Surg. Med. 30,141-148 (2002). [CrossRef]
  14. R. O. Esenaliev, Y. Y. Petrov, O. Hartrumpf, D. J. Deyo, and D. S. Prough, "Continuous, noninvasive monitoring of total hemoglobin concentration by an optoacoustic technique," Appl. Opt. 43,3401-3407 (2004). [CrossRef] [PubMed]
  15. I. Patrikeev, Y.Y. Petrov, I.Y. Petrova, D.S. Prough, and R.O. Esenaliev, "Monte Carlo modeling of optoacoustic signals from large veins: implication for noninvasive monitoring of cerebral blood oxygenation," in Biomedical Digest (Optical Society of America, 2006), paper SH64.
  16. Y. Y. Petrov, D. S. Prough, D. J. Deyo, I. Y. Petrova, M. Motamedi, R. O. Esenaliev, "In vivo noninvasive monitoring of cerebral blood oxygenation with optoacoustic technique," in Proceedings of the 26th Intern. Conf. of IEEE EMBS, San Francisco, CA, Sept. 1-5, 2004, 2052-2054.
  17. Y. Y. Petrov, D. S. Prough, D. J. Deyo, M. Klasing, M. Motamedi, and R. O. Esenaliev, "Optoacoustic, noninvasive, real-time, continuous monitoring of cerebral blood oxygenation: An in vivo study in sheep," Anesthesiology 102,69-75 (2005). [CrossRef]
  18. I. Y. Petrova, R. O. Esenaliev, Y. Y. Petrov, H. P. Brecht, C. H. Svensen, J. Olsson, D. J. Deyo, and D. S. Prough, "Optoacoustic monitoring of blood hemoglobin concentration: a pilot clinical study," Opt. Lett. 30,1677-1679 (2005). [CrossRef] [PubMed]
  19. J. Laufer, D. Delpy, C. Elwell, and P. Beard, "Quantitative spatially resolved measurement of tissue chromophore concentrations using photoacoustic spectroscopy: application to the measurement of blood oxygenation and haemoglobin concentration," Phys. Med. Biol. 52, 141-168, (2007). [CrossRef]
  20. "ANSI Z136.1 - 2000" in American national standard for safe use of lasers, (The Laser Institute of America, Orlando, FL 2000).
  21. Y. Y. Petrov, I. Y. Petrova, I. A. Patrikeev, R. O. Esenaliev, and D. S. Prough, "Multiwavelength optoacoustic system for noninvasive monitoring of cerebral venous oxygenation: a pilot clinical test in the internal jugular vein," Opt. Lett. 31,1827-1829 (2006). [CrossRef] [PubMed]
  22. A. A. Karabutov, E. V. Savateeva, N. B. Podymova, and A. A. Oraevsky, "Backward mode detection of laser-induced wide- band ultrasonic transients with optoacoustic transducer," J. Appl. Phys. 87,2003-2014 (2000). [CrossRef]
  23. I. Patrikeev, Y. Y. Petrov, I. Y. Petrova, D. S. Prough, and R. O. Esenaliev, "Monte Carlo modeling of optoacoustic signals from human internal jugular veins," Appl. Opt. 46, 4820-4827 (2007). [CrossRef] [PubMed]
  24. S. Prahl, "Optical Absorption of Hemoglobin," http://omlc.ogi.edu/spectra/hemoglobin/index.html.
  25. W. F. Cheong, S. A. Prahl, and A. J Welch, "A review of the optical properties of biological tissues" IEEE Trans. Med. Imaging 26,2166-2185 (1990).
  26. A. N. Yaroslavsky, I. V. Yarovslavsky, T Goldbach, and G. H. Sembrosk, "The Optical Properties of blood in the near infrared spectral range," Proc. SPIE 2678, 314-324 (1996). [CrossRef]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited