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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 15, Iss. 25 — Dec. 10, 2007
  • pp: 16657–16666

Ex vivo Characterization of Atherosclerosis using Intravascular Photoacoustic Imaging

Shriram Sethuraman, James H. Amirian, Silvio H. Litovsky, Richard W. Smalling, and Stanislav Y. Emelianov  »View Author Affiliations

Optics Express, Vol. 15, Issue 25, pp. 16657-16666 (2007)

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The assessment of plaque composition is one of the important steps in the interventional management of atherosclerosis. The difference in the optical absorption between the arterial wall and plaque constituents could be utilized to obtain high resolution photoacoustic images. Therefore, intravascular photoacoustic (IVPA) imaging has the potential to play a major role in the detection and differentiation of atherosclerotic lesions. Using a rabbit model of atherosclerosis, we performed ex vivo imaging studies to evaluate the ability of IVPA imaging to detect the presence of inflammation in the plaque. Specifically, the difference in the magnitude of the photoacoustic response from the free lipids, macrophage foam cells, blood and the rest of the arterial wall were used in detecting the fibro-cellular inflammatory plaque. The constituents identified in the IVPA images were confirmed by the results from histology.

© 2007 Optical Society of America

OCIS Codes
(110.5120) Imaging systems : Photoacoustic imaging
(110.7170) Imaging systems : Ultrasound
(170.2150) Medical optics and biotechnology : Endoscopic imaging
(170.3880) Medical optics and biotechnology : Medical and biological imaging

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: September 4, 2007
Revised Manuscript: November 28, 2007
Manuscript Accepted: November 29, 2007
Published: November 30, 2007

Virtual Issues
Vol. 3, Iss. 1 Virtual Journal for Biomedical Optics

Shriram Sethuraman, James H. Amirian, Silvio H. Litovsky, Richard W. Smalling, and Stanislav Y. Emelianov, "Ex vivo Characterization of Atherosclerosis using Intravascular Photoacoustic Imaging," Opt. Express 15, 16657-16666 (2007)

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