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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 15, Iss. 25 — Dec. 10, 2007
  • pp: 16657–16666

Ex vivo Characterization of Atherosclerosis using Intravascular Photoacoustic Imaging

Shriram Sethuraman, James H. Amirian, Silvio H. Litovsky, Richard W. Smalling, and Stanislav Y. Emelianov  »View Author Affiliations


Optics Express, Vol. 15, Issue 25, pp. 16657-16666 (2007)
http://dx.doi.org/10.1364/OE.15.016657


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Abstract

The imaging of plaque composition represents one of the important steps in the interventional management of atherosclerosis. Intravascular photoacoustic (IVPA) imaging has the potential to play a major role in the detection and differentiation of an atherosclerotic lesion. The difference in the optical properties of the arterial wall and plaque constituents could be utilized to obtain high resolution photoacoustic images. In this work, through ex vivo imaging studies using a rabbit model of atherosclerosis, we evaluate the ability of IVPA imaging to detect and characterize the plaque. Specifically, the difference in the magnitude of the photoacoustic signals from the free lipids, macrophage foam cells, blood and the rest of the arterial wall were helpful in providing the contrast and detecting the fibro-cellular inflammatory plaque. The constituents identified in the IVPA images were confirmed by the results from histology.

© 2007 Optical Society of America

OCIS Codes
(110.5120) Imaging systems : Photoacoustic imaging
(110.7170) Imaging systems : Ultrasound
(170.2150) Medical optics and biotechnology : Endoscopic imaging
(170.3880) Medical optics and biotechnology : Medical and biological imaging

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: September 4, 2007
Revised Manuscript: November 28, 2007
Manuscript Accepted: November 29, 2007
Published: November 30, 2007

Virtual Issues
Vol. 3, Iss. 1 Virtual Journal for Biomedical Optics

Citation
Shriram Sethuraman, James H. Amirian, Silvio H. Litovsky, Richard W. Smalling, and Stanislav Y. Emelianov, "Ex vivo Characterization of Atherosclerosis using Intravascular Photoacoustic Imaging," Opt. Express 15, 16657-16666 (2007)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-15-25-16657


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