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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 15, Iss. 25 — Dec. 10, 2007
  • pp: 16808–16817

Three dimensional tracking for volumetric spectral-domain optical coherence tomography

Gopi Maguluri, Mircea Mujat, B.H. Park, K.H. Kim, Wei Sun, N.V. Iftimia, R. Daniel Ferguson, Daniel X. Hammer, Teresa C. Chen, and Johannes F. de Boer  »View Author Affiliations

Optics Express, Vol. 15, Issue 25, pp. 16808-16817 (2007)

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We present a three-dimensional (3D) tracker for a clinical ophthalmic spectral domain optical coherence tomography (SD-OCT) system that combines depth-tracking with lateral tracking, providing a stabilized reference frame for 3D data recording and post acquisition analysis. The depth-tracking system is implemented through a real-time dynamic feedback mechanism to compensate for motion artifact in the axial direction. Active monitoring of the retina and adapting the reference arm of the interferometer allowed the whole thickness of the retina to be stabilized to within ±100 µm. We achieve a relatively constant SNR from image to image by stabilizing the image of the retina with respect to the depth dependent sensitivity of SD-OCT. The depth tracking range of our system is 5.2 mm in air and the depth is adjusted every frame. Enhancement in the stability of the images with the depth-tracking algorithm is demonstrated on a healthy volunteer.

© 2007 Optical Society of America

OCIS Codes
(110.6880) Imaging systems : Three-dimensional image acquisition
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.4470) Medical optics and biotechnology : Ophthalmology
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(200.4560) Optics in computing : Optical data processing

ToC Category:
Imaging Systems

Original Manuscript: August 17, 2007
Revised Manuscript: November 14, 2007
Manuscript Accepted: November 18, 2007
Published: December 3, 2007

Virtual Issues
Vol. 3, Iss. 1 Virtual Journal for Biomedical Optics

Gopi Maguluri, Mircea Mujat, B. H. Park, K. H. Kim, Wei Sun, N. V. Iftimia, R. D. Ferguson, Daniel X. Hammer, Teresa C. Chen, and Johannes F. de Boer, "Three dimensional tracking for volumetric spectral-domain optical coherence tomography," Opt. Express 15, 16808-16817 (2007)

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  1. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, "Optical coherence tomography," Science 254,1178-1181 (1991). [CrossRef] [PubMed]
  2. A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. El-Zaiat, "Measurements of intraocular distances by backscattering spectral interferometry," Opt. Commun. 117,43-48 (1995). [CrossRef]
  3. M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, "In vivo human retinal imaging by Fourier domain optical coherence tomography," J. Biomed. Opt. 7,457-463 (2002). [CrossRef] [PubMed]
  4. N. Nassif, B. Cense, B. H. Park, S. H. Yun, T. C. Chen, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "In vivo human retinal imaging by ultrahigh-speed spectral domain optical coherence tomography," Opt. Lett. 29,480-482 (2004). [CrossRef] [PubMed]
  5. T. C. Chen, B. Cense, M. C. Pierce, N. Nassif, B. H. Park, S. H. Yun, B. R. White, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Spectral domain optical coherence tomography - Ultra-high speed, ultra-high resolution ophthalmic imaging," Arch. Ophthalmol. 123,1715-1720 (2005). [CrossRef] [PubMed]
  6. S. H. Yun, G. J. Tearney, J. F. de Boer, and B. E. Bouma, "Motion artifacts in optical coherence tomography with frequency-domain ranging," Opt. Express 12,2977-2998 (2004). [CrossRef] [PubMed]
  7. R. D. Ferguson, D. X. Hammer, L. A. Paunescu, S. Beaton, and J. S. Schuman, "Tracking optical coherence tomography," Opt. Lett. 29,2139-2141 (2004). [CrossRef] [PubMed]
  8. D. X. Hammer, R. Daniel Ferguson, NicusorV. Iftimia, Teoman Ustun, G. Wollstein, H. Ishikawa, Michelle L. Gabriele, William D. Dilworth, Larry Kagemann and Jeol S. Schuman, "Advanced scanning methods with tracking optical coherence tomography," Opt. Express 13,7937-7947 (2005). [CrossRef] [PubMed]
  9. N. A. Nassif, B. Cense, B. H. Park, M. C. Pierce, S. H. Yun, B. E. Bouma, G. J. Tearney, T. C. Chen, and J. F. de Boer, "In vivo high-resolution video-rate spectral-domain optical coherence tomography of the human retina and optic nerve," Opt. Express 12,367-376 (2004). [CrossRef] [PubMed]
  10. N. V. Iftimia, B. E. Bouma, J. F. de Boer, B. H. Park, B. Cense, and G. J. Tearney, "Adaptive ranging for optical coherence tomography," Opt. Express 12,4025-4034 (2004). [CrossRef] [PubMed]
  11. G. J. Tearney, B. E. Bouma, and J. G. Fujimoto, "High-speed phase- and group-delay scanning with a grating-based phase control delay line," Opt. Lett. 22,1811-1813 (1997). [CrossRef]
  12. B. H. Park, M. C. Pierce, B. Cense, and J. F. de Boer, "Real-time multi-functional optical coherence tomography," Opt. Express 11,782-793 (2003). [CrossRef] [PubMed]
  13. N. V. Iftimia, C. E. Bigelow, T. Ustun, J. F. de Boer, R. D. Ferguson, "Hybrid retinal imager using line-scanning laser ophthalmoscopy and spectral domain optical coherence tomography," Opt. Express 14,12909 - 12914 (2006). [CrossRef] [PubMed]
  14. D. X. Hammer, R. Daniel Ferguson, J. C. Magill, L. A. Paunescu, S. Beaton, H. Ishikawa, G. Wollstein, J. S. Shuman, "Active retinal tracker for clinical optical coherence tomography," J. Biomed. Opt. 10, Art. No. 024038 (2005). [CrossRef] [PubMed]
  15. M. Mujat, R. C. Chan, B. Cense, B. H. Park, C. Joo, T. Akkin, T. C. Chen, and J. F. de Boer, "Retinal nerve fiber layer thickness map determined from optical coherence tomography images," Opt. Express 13,9480-9491 (2005). [CrossRef] [PubMed]
  16. S. L. Jiao, R. Knighton, X. R. Huang, G. Gregori, and C. A. Puliafito, "Simultaneous acquisition of sectional and fundus ophthalmic images with spectral-domain optical coherence tomography," Opt. Express 13,444-452 (2005). [PubMed]

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