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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 15, Iss. 25 — Dec. 10, 2007
  • pp: 17001–17009

Microrheology of red blood cell membranes using dynamic scattering microscopy

M. Shahrooz Amin, YoungKeun Park, Niyom Lue, Ramachandra R. Dasari, Kamran Badizadegan, Michael S. Feld, and Gabriel Popescu  »View Author Affiliations

Optics Express, Vol. 15, Issue 25, pp. 17001-17009 (2007)

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We employ a novel optical technique, dynamic scattering microscopy (DSM), to extract the frequency dependence of the viscoelastic modulus associated with the red blood cell membrane. This approach applies the principle of dynamic light scattering to micro beads attached to the red blood cell membrane in thermal fluctuation. This allows for high-throughput characterization of a large number of cells simultaneously, which represents a significant advantage over current methods. The results in terms of the effective loss and storage moduli indicate the generic behavior of a viscoelastic material, characterized by power laws with exponents between 0 and 1.

© 2007 Optical Society of America

OCIS Codes
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(180.0180) Microscopy : Microscopy

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: September 17, 2007
Revised Manuscript: November 26, 2007
Manuscript Accepted: November 27, 2007
Published: December 5, 2007

Virtual Issues
Vol. 3, Iss. 1 Virtual Journal for Biomedical Optics

M. Shahrooz Amin, YougKeun Park, Niyom Lue, Ramachandra R. Dasari, Kamran Badizadegan, Michael S. Feld, and Gabriel Popescu, "Microrheology of red blood cell membranes using dynamic scattering microscopy," Opt. Express 15, 17001-17009 (2007)

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