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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 15, Iss. 26 — Dec. 24, 2007
  • pp: 17661–17672

Optimal self-referenced sensing using long- and short- range surface plasmons

J. T. Hastings, J. Guo, P. D. Keathley, P. B. Kumaresh, Y. Wei, S. Law, and L. G. Bachas  »View Author Affiliations

Optics Express, Vol. 15, Issue 26, pp. 17661-17672 (2007)

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Dual-mode surface-plasmon resonance (SPR) sensors use both long- and short- range surface plasmon waves to differentiate surface binding interactions from interfering bulk effects. We have optimized the design of these sensors for minimum surface limit of detection (LOD) using a Cramer-Rao lower bound for spectral shift estimation. Despite trade-offs between resonance width, minimum reflectivity, and sensitivity for the two modes, a range of reasonable design parameters provides nearly optimal performance. Experimental verification using biotin-streptavidin binding as a model system reveals that sensitivity and LOD for dual-mode sensors remains competitive with single-mode sensors while compensating for bulk effects.

© 2007 Optical Society of America

OCIS Codes
(240.6680) Optics at surfaces : Surface plasmons
(280.4788) Remote sensing and sensors : Optical sensing and sensors

ToC Category:
Optics at Surfaces

Original Manuscript: October 31, 2007
Revised Manuscript: November 29, 2007
Manuscript Accepted: December 1, 2007
Published: December 12, 2007

Virtual Issues
Vol. 3, Iss. 1 Virtual Journal for Biomedical Optics

J. T. Hastings, J. Guo, P. D. Keathley, P. B. Kumaresh, Y. Wei, S. Law, and L. G. Bachas, "Optimal self-referenced sensing using long- and short- range surface plasmons," Opt. Express 15, 17661-17672 (2007)

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