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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 15, Iss. 26 — Dec. 24, 2007
  • pp: 17819–17826

Detection of quantum-dot labeled proteins using soft glass microstructured optical fibers

Yinlan Ruan, Erik P. Schartner, Heike Ebendorff-Heidepriem, Peter Hoffmann, and Tanya M. Monro  »View Author Affiliations


Optics Express, Vol. 15, Issue 26, pp. 17819-17826 (2007)
http://dx.doi.org/10.1364/OE.15.017819


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Abstract

The detection of quantum-dot labeled proteins is demonstrated within lead silicate soft glass microstructured optical fibers using near infrared light. The protein concentration is measured using a new fluorescence capture approach. Light guided within the fiber is used both to excite and collect fluorescent photons, and the detection limit achieved without optimization of the fiber geometry is 1 nM, using just 3% of the guided mode of the fiber. Issues that currently restrict the detection of lower protein concentrations are discussed.

© 2007 Optical Society of America

OCIS Codes
(060.2370) Fiber optics and optical communications : Fiber optics sensors
(170.6280) Medical optics and biotechnology : Spectroscopy, fluorescence and luminescence
(300.1030) Spectroscopy : Absorption
(300.2140) Spectroscopy : Emission

ToC Category:
Fiber Optics and Optical Communications

History
Original Manuscript: November 1, 2007
Revised Manuscript: December 10, 2007
Manuscript Accepted: December 11, 2007
Published: December 13, 2007

Virtual Issues
Vol. 3, Iss. 1 Virtual Journal for Biomedical Optics

Citation
Yinlan Ruan, Erik P. Schartner, Heike Ebendorff-Heidepriem, Peter Hoffmann, and Tanya M. Monro, "Detection of quantum-dot labelled proteins using soft glass microstructured optical fibers," Opt. Express 15, 17819-17826 (2007)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-15-26-17819


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References

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