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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 15, Iss. 3 — Feb. 5, 2007
  • pp: 1064–1075

Validation of diffuse correlation spectroscopy for muscle blood flow with concurrent arterial spin labeled perfusion MRI

Guoqiang Yu, Thomas F. Floyd, Turgut Durduran, Chao Zhou, Jiongjiong Wang, John A. Detre, and Arjun G. Yodh  »View Author Affiliations

Optics Express, Vol. 15, Issue 3, pp. 1064-1075 (2007)

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Calf blood flow was measured simultaneously in healthy human subjects (n = 7) during cuff inflation and deflation using near-infrared diffuse correlation spectroscopy (DCS) and arterial spin labeled perfusion MRI (ASL-MRI). The DCS and ASL-MRI data exhibited highly correlated absolute and relative dynamic flow responses in each individual (p < 0.001). Peak flow variations during hyperemia were also significantly correlated, though more for relative (p = 0.003) than absolute (p = 0.016) flow. Repeated measurement variation was less than 8% for both modalities. The results provide much needed quantitative blood flow validation of the diffuse optical correlation method in humans.

© 2007 Optical Society of America

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6480) Medical optics and biotechnology : Spectroscopy, speckle

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: November 3, 2006
Revised Manuscript: January 14, 2007
Manuscript Accepted: January 16, 2007
Published: February 5, 2007

Virtual Issues
Vol. 2, Iss. 3 Virtual Journal for Biomedical Optics

Guoqiang Yu, Thomas F. Floyd, Turgut Durduran, Chao Zhou, Jiongjiong Wang, John A. Detre, and Arjun G. Yodh, "Validation of diffuse correlation spectroscopy for muscle blood flow with concurrent arterial spin labeled perfusion MRI," Opt. Express 15, 1064-1075 (2007)

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