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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 15, Iss. 6 — Mar. 19, 2007
  • pp: 3301–3311

Time-resolved diffuse optical spectroscopy of small tissue samples

Paola Taroni, Daniela Comelli, Andrea Farina, Antonio Pifferi, and Alwin Kienle  »View Author Affiliations


Optics Express, Vol. 15, Issue 6, pp. 3301-3311 (2007)
http://dx.doi.org/10.1364/OE.15.003301


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Abstract

Time-resolved transmittance spectroscopy was performed in the wavelength range of 610 or 700 to 1050 nm on phantom parallelepipeds and bone tissue cubes of different sizes. The data were best fitted with solutions of the diffusion equation for a laterally infinite slab and for a parallelepiped to investigate how size and optical properties of the samples affect the results obtained with the two models. Monte Carlo simulations were also performed to support and help with the interpretation of the experimental data. The parallelepiped model performs much better than the infinite slab model for the estimate of the reduced scattering coefficient and, even more, the absorption coefficient. It can profitably be used to quantify the optical properties of biological tissue samples and to derive information such as tissue composition, when small volumes are involved.

© 2007 Optical Society of America

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.5280) Medical optics and biotechnology : Photon migration
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(290.1990) Scattering : Diffusion

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: January 17, 2007
Revised Manuscript: February 27, 2007
Manuscript Accepted: March 1, 2007
Published: March 19, 2007

Virtual Issues
Vol. 2, Iss. 4 Virtual Journal for Biomedical Optics

Citation
Paola Taroni, Daniela Comelli, Andrea Farina, Antonio Pifferi, and Alwin Kienle, "Time-resolved diffuse optical spectroscopy of small tissue samples," Opt. Express 15, 3301-3311 (2007)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-15-6-3301


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