OSA's Digital Library

Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 15, Iss. 7 — Apr. 2, 2007
  • pp: 4039–4053

Light scattering and microarchitectural differences between tumorigenic and non-tumorigenic cell models of tissue

Janak Ramachandran, Tamara M. Powers, Susan Carpenter, Alicia Garcia-Lopez, James P. Freyer, and Judith R. Mourant  »View Author Affiliations


Optics Express, Vol. 15, Issue 7, pp. 4039-4053 (2007)
http://dx.doi.org/10.1364/OE.15.004039


View Full Text Article

Enhanced HTML    Acrobat PDF (696 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

Differences in light scattering properties of a tumorigenic and a non-tumorigenic model for tissue were demonstrated using a variety of light scattering techniques, the majority of which are in vivo compatible. In addition to determining that light scattering differences exist, models for the microarchitectural changes responsible for the light scattering differences were developed.

© 2007 Optical Society of America

OCIS Codes
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(290.7050) Scattering : Turbid media

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: October 31, 2006
Revised Manuscript: February 8, 2007
Manuscript Accepted: March 13, 2007
Published: April 2, 2007

Virtual Issues
Vol. 2, Iss. 5 Virtual Journal for Biomedical Optics

Citation
Janak Ramachandran, Tamara M. Powers, Susan Carpenter, Alicia Garcia-Lopez, James P. Freyer, and Judith R. Mourant, "Light scattering and microarchitectural differences between tumorigenic and non-tumorigenic cell models of tissue," Opt. Express 15, 4039-4053 (2007)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-15-7-4039


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. L. A. Kunz-Schughart, A. Simm, andW. Mueller-Klieser, "Oncogene-associated transformation of rodent fibroblasts is accompanied by large morphologic and metabolic alterations," Oncol. Rep. 2, 651-661(1995).
  2. B.F. Hochheimer, "Polarized light retinal photography of a monkey eye," Vision Res,"  18,19-23 (1978). [CrossRef] [PubMed]
  3. A. H. Hielscher, J. R. Mourant, I. J. Bigio, "Influence of particle size and concentration on the diffuse backscattering of polarized light from tissue phantoms and biological cell suspensions," Appl. Opt. 36, 125-135(1997). [CrossRef] [PubMed]
  4. A. I. Carswell, and S. R. Pal, "Polarization anisotropy in lidar multiple scattering from clouds," Appl. Opt. 19, 4123-4126 (1980). [CrossRef] [PubMed]
  5. M. Dogairu and T. Asakaru, "Polarization-dependent backscattering patterns from weakly scattering media," J. Opt. (Paris)  24, 271-278 (1993). [CrossRef]
  6. M. J. Rakovic, G. W. Kattawar, "Theoretical analysis of polarization patterns from incoherent backscattering of light," Appl. Opt. 37, 3333-3338 (1998). [CrossRef]
  7. T. M. Johnson and J. R. Mourant, "Polarized wavelength-dependent measurements of turbid media," Opt. Express 6, 200-216 (1999). [CrossRef]
  8. M. R. Ostermeyer, D. V. Stephens, L. Wang, and S. L. Jacques "Nearfiled polarization effects on light propagation in random media," in: OSA TOPS on Biomedical Optical Spectroscopy and Diagnostics, E. Sevick-Muraca and D. Benaron, Eds., Vol. 3. pp. 20-25 (1996).
  9. K. Sokolov, R. Drezek, K. Gossagee and R. Richards-Kortum, "Reflectance spectroscopy with polarized light : Is it sensitive to cellular and nuclear morphology," Opt Express 5, 302-317 (1999). [CrossRef] [PubMed]
  10. V. Backman, R. Gurjar, K. Badizadegan, I. Itzkan, R. R. Dasari, L. T. Perelman and M. S. Feld, "Polarized light scattering spectroscopy for quantitative measurement of epithelial cellular structures in situ," IEEE J. Quantum Electron. 5, 1019-1026(1999). [CrossRef]
  11. J. R. Mourant, T. M. Johnson and J. P. Freyer, "Characterizing mammalian cells and cell phantoms by polarized backscattering fiber-optic measurements," Appl. Opt. 40, 5114-5123 (2001). [CrossRef]
  12. A. Myakov, L. Nieman, L. Wicky, U. Utzinger, R. Richards-Kortum and K. Sokolov, "Fiber optic probe for polarized reflectance spectrocopy in vivo : Design and performance," J. Biomed. Opt. 7, 388-397 (2002). [CrossRef] [PubMed]
  13. L. Nieman, A. Myakov, J. Aaron, K. Soklov, "Optical sectioning using a fiber probe with an angled illuminationcollection geometry: evaluation in engineered tissue phantoms," Appl. Opt. 43, 1308 - 1319 (2004). [CrossRef] [PubMed]
  14. J. R. Mourant, T. M. Johnson, S. Carpenter, A. Guerra, J. P. Freyer, "Polarized angular dependent spectroscopy of epithelial cells and epithelial nuclei to determine the size scale of scattering structures," J. Biomed. Opt. 7, 378-387 (2002). [CrossRef] [PubMed]
  15. J. D. Wilson, and T. M. Foster, "Mie theory interpretations of light scattering from intact cells," Opt. Lett. 30, 2442-2444 (2005). [CrossRef] [PubMed]
  16. M. Bartlett, G. Huang, L. Larcom, and H. Jiang, "Measurement of particle size distribution in mammalian cells in vitro by use of polarized light spectroscopy," Appl. Opt. 43, 1296-1307 (2004). [CrossRef] [PubMed]
  17. J. M. Schmitt and G. Kumar, "Turbulent nature of refractive-index variations in biological tissue," Opt. Lett. 21, 1310-1312 (1996). [CrossRef] [PubMed]
  18. D. Passos, J.C. Hebden, P.N. Pinto, R. Guerra, "Tissue phantom for optical diagnostics based on a suspension of microspheres with a fractal size distribution," J. Biomed. Opt. 10, 064036-1—11, (2005). [CrossRef]
  19. B. Gelebart, E. Tinet, J.M. Tualle, S. Avriller, "Phase function simulation in tissue phantoms: a fractal approach," Pure Appl. Opt. 5, 377-388 (1996). [CrossRef]
  20. M. Xu and R. R. Alfano, "Fractal mechanisms of light scattering in biological tissue and cells," Opt. Lett. 30, 3051-3053 (2005). [CrossRef] [PubMed]
  21. H. Fang, M. Ollero, E. Vitkin, L. M. Kimerer, P. B. Cipolloni, M. N. Zaman, S. D. Freedman, I. J. Bigio, I. Itzkan, E. B. Hanlon, and L. T. Perelman, "Noninvasive sizing of subcellular organelles with light scattering spectroscopy," IEEE J. Sel. Top. Quantum Electron. 9, 267-276 (2003). [CrossRef]
  22. L. Wang and S. L. Jacques, "Use of a laser beam with oblique angle to measure the reduced scattering coefficient of a turbid medium," Appl. Opt. 34, 2362-2366 (1995). [CrossRef] [PubMed]
  23. J. R. Mourant, J. P. Freyer, A. H. Hielscher, A. A. Eick, D. Shen, and T. M. Johnson, "Mechanisms of light scattering from biological cells relevant to noninvasive optical-tissue diagnostics," Appl Opt. 37, 3586-3593 (1998). [CrossRef]
  24. J. R. Mourant, M. Canpolat, C. Broker, O. Esponda-Ramos, T. Johnson, A. Matanock, K. Stetter, and J.P. Freyer, "Light scattering from cells: the contribution of the nucleus and the effects of proliferative status," J. Biomed. Opt. 5, 131-137 (2000). [CrossRef] [PubMed]
  25. J. R. Mourant, S. Carpenter, K. W. Short, P. Kunapareddy, L. Coburn and J. P. Freyer "Biochemical differences in tumorigenic and non-tumorigenic cells measured by Raman and infrared spectroscopy," J. Biomed. Opt. 10, 031106-1 to 031106-15 (2005). [CrossRef]
  26. J. R. Mourant, A. H. Hielscher, A. A. Eick, T. M. Johnson, J. P. Freyer, "Evidence of intrinsic differences in the light scattering properties of tumorigienic and nontumorigenic cells," Cancer Cytopath. 84, 366-374 (1998).
  27. M. I. Mischenko and L. D. Travis, "Capabilities and limitations of a current fortran implementation of the Tmatrix method for randomly oriented, rotationally symmetric scatterers," J. Quantum Spectrosc. Radiat. Transf. 60, 309324 (1998).
  28. J. R. Mourant, T.J. Bocklage, T. M. Powers, H. M. Greene, K. L. Bullock,L. R. Marr-Lyon, M. H. Dorin, A. G. Waxman, M. M. Zsemlye, and H. O. Smith, "In vivo light scattering measurements for detection of precancerous conditions of the cervix," accepted Gynecological Oncology 2007.
  29. R. Drezek, M. Guillard, T. Collier, I. Biodo, A. Malpica, C. Macaulay, M. Follen, R. Richards-Kortum, "Light scattering from cervical cells throughout neoplastic progression: influence of nuclear morphology, DNA content, and chromatin texture," J. Biomed. Opt. 8, 7-16 (2003). [CrossRef] [PubMed]
  30. A. Wax, C. Yang, M. G. M¨uller, R. Nines, C. W. Boone, V. E. Steele, G. D. Stoner, R. R. Dasari, M. S. Feld, "In situ detection of neoplastic transformation and chemopreventive effects in rat esophagus epithelium using angle-resolved log coherence interferometry," Cancer Research,  63, 3556-3559 (2003). [PubMed]
  31. Y. L. Kim, Y. Liu, R. K. Wali, H. K. Roy,M. J. Goldberg, A. K. Kromin, K. Chen, and V. Backman, "Simultaneous measurement of angular and spectral properties of light scattering for characterization of tissue microarchitecture and its alteration in early precancer," IEEE J. Qunatum Electron. 9, 243-256 (2003). [CrossRef]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited