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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 16, Iss. 1 — Jan. 7, 2008
  • pp: 19–31

Inspiratory contrast for in vivo optical imaging

Kenneth T. Kotz, Sanhita S. Dixit, Ashley D. Gibbs, Juan M. Orduna, Zishan Haroon, Khalid Amin, and Gregory W. Faris  »View Author Affiliations

Optics Express, Vol. 16, Issue 1, pp. 19-31 (2008)

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We demonstrate the use of inspired oxygen and carbon dioxide as a possible route to increase contrast in optical imaging of cancerous tissue. Differential imaging in human xenograft rodent models of cancer exhibits significant variation in signal between normal and cancerous tissue. This differential cancer-specific contrast is stronger and more consistent than the conventional static contrast. This differential technique exploits the response of abnormal tumor vasculature to inhaled gases and could provide a promising alternative to supplement mainstream cancer imaging modalities such as x-rays and MRI.

© 2008 Optical Society of America

OCIS Codes
(170.0110) Medical optics and biotechnology : Imaging systems
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.5280) Medical optics and biotechnology : Photon migration
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(170.6930) Medical optics and biotechnology : Tissue

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: October 17, 2007
Revised Manuscript: December 3, 2007
Manuscript Accepted: December 17, 2007
Published: December 21, 2007

Virtual Issues
Vol. 3, Iss. 2 Virtual Journal for Biomedical Optics

Kenneth T. Kotz, Sanhita S. Dixit, Ashley D. Gibbs, Juan M. Orduna, Zishan Haroon, Khalid Amin, and Gregory W. Faris, "Inspiratory contrast for in vivo optical imaging," Opt. Express 16, 19-31 (2008)

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