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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 16, Iss. 1 — Jan. 7, 2008
  • pp: 304–314

Inverse optical design of the human eye using likelihood methods and wavefront sensing

Julia A. Sakamoto, Harrison H. Barrett, and Alexander V. Goncharov  »View Author Affiliations

Optics Express, Vol. 16, Issue 1, pp. 304-314 (2008)

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We are developing a method for estimating patient-specific ocular parameters, including surface curvatures, conic constants, tilts, decentrations, thicknesses, refractive indices, and index gradients. The data consist of the raw detector outputs from one or more Shack-Hartmann wavefront sensors, and the parameters in the eye model are estimated by maximizing the likelihood. A Gaussian noise model is used to emulate electronic noise, so maximum likelihood reduces to nonlinear least-squares fitting between the data and the output of our optical design program. The Fisher information matrix for the Gaussian model was explored to compute bounds on the variance of the estimates for different system configurations. In this preliminary study, an accurate estimate of a chosen subset of ocular parameters was obtained using a custom search algorithm and a nearby starting point to avoid local minima in the complex likelihood surface.

© 2008 Optical Society of America

OCIS Codes
(010.7350) Atmospheric and oceanic optics : Wave-front sensing
(170.4460) Medical optics and biotechnology : Ophthalmic optics and devices
(170.4470) Medical optics and biotechnology : Ophthalmology
(220.2740) Optical design and fabrication : Geometric optical design

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: September 18, 2007
Revised Manuscript: December 12, 2007
Manuscript Accepted: December 13, 2007
Published: January 4, 2008

Virtual Issues
Vol. 3, Iss. 2 Virtual Journal for Biomedical Optics

Julia A. Sakamoto, Harrison H. Barrett, and Alexander V. Goncharov, "Inverse optical design of the human eye using likelihood methods and wavefront sensing," Opt. Express 16, 304-314 (2008)

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