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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 16, Iss. 10 — May. 12, 2008
  • pp: 7453–7459

Nanoscale depth resolution in scanning near-field infrared microscopy

Götz Wollny, Erik Bründermann, Zoran Arsov, Luca Quaroni, and Martina Havenith  »View Author Affiliations

Optics Express, Vol. 16, Issue 10, pp. 7453-7459 (2008)

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We have recorded nanoscale topography and infrared chemical fingerprints of attomole layered lipids consisting of dimyristoylphosphatidylcholine on silicon and mica. Lipids deposited on mica built stacks consisting of up to 25 bilayers, each approximately 5 nm thick, spanning a range from 5–125 nm in height. Contrast evaluation as a function of layer thickness provides the near-field depth resolution.

© 2008 Optical Society of America

OCIS Codes
(110.3080) Imaging systems : Infrared imaging
(180.5810) Microscopy : Scanning microscopy
(300.6340) Spectroscopy : Spectroscopy, infrared

ToC Category:

Original Manuscript: February 27, 2008
Revised Manuscript: April 13, 2008
Manuscript Accepted: April 30, 2008
Published: May 8, 2008

Virtual Issues
Vol. 3, Iss. 6 Virtual Journal for Biomedical Optics

Götz Wollny, Erik Bründermann, Zoran Arsov, Luca Quaroni, and Martina Havenith, "Nanoscale depth resolution in scanning near-field infrared microscopy," Opt. Express 16, 7453-7459 (2008)

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  1. A. Egner, S. Jacobs, and St. Hell, "Fast 100-nm resolution three-dimensional microscope reveals structural plasticity of mitochondria in live yeast," Proc. Natl. Acad. Sci. 99, 3370-3375 (2002). [CrossRef] [PubMed]
  2. G. Seisenberger, M. U. Ried, Th. Endre�?, H. Büning, M. Hallek, and Ch. Bräuchle, "Real-time single-molecule imaging of the infection pathway of an adeno-associated virus," Science 294, 1929-1932 (2001). [CrossRef] [PubMed]
  3. M. Diem, M. Romeo, C. Matthäus, M. Miljkovic, L. Miller, and P. Lasch, "Comparison of Fourier transform infrared (FTIR) spectra of individual cells acquired using synchrotron and conventional sources," Infrared Phys. Technol. 45, 331-338 (2004). [CrossRef]
  4. A. Hartschuh, H. Qian, A. J. Meixner, N. Anderson, L. Novotny, "Tip-enhanced optical spectroscopy for surface analysis in biosciences," Surf. Interface Anal. 381472-1480 (2006). [CrossRef]
  5. D. Courjon and C. Bainier, "Near field microscopy and near field optics," Rep. Prog. Phys. 57, 989-1028 (1994). [CrossRef]
  6. B. Dragnea and S. R. Leone, "Advances in submicron infrared vibrational band chemical imaging," Int. Rev. Phys. Chem. 20, 59-92 (2001). [CrossRef]
  7. F. Keilmann and R. Hillenbrand, "Near-field microscopy by elastic light scattering from a tip," Phil. Trans. R. Soc. Lond. A 362, 787-805 (2004). [CrossRef]
  8. T. Taubner, F. Keilmann, and R. Hillenbrand, "Nanoscale-resolved subsurface imaging by scattering-type near-field optical microscopy," Opt. Express 13, 8893-8899 (2005). [CrossRef] [PubMed]
  9. N. Anderson, P. Anger, A. Hartschuh, L. Novotny, "Subsurface Raman Imaging with Nanoscale Resolution," Nano Lett. 6, 744-749 (2006). [CrossRef] [PubMed]
  10. J. S. Samson, G. Wollny, E. Bründermann, A. Bergner, A. Hecker, G. Schwaab, A. D. Wieck, and M. Havenith, "Setup of a scanning near field infrared microscope (SNIM): Imaging of sub-surface nano-structures in galliumdoped silicon," Phys. Chem. Chem. Phys. 8, 753-758 (2006). [CrossRef] [PubMed]
  11. A. Cvitkovic, N. Ocelic, and R. Hillenbrand, "Analytical model for quantitative prediction of material contrasts in scattering-type near-field optical microscopy," Opt. Express 15, 8550-8565 (2007). [CrossRef] [PubMed]
  12. J. Aizpurua, T. Taubner, F. J. García de Abajo, M. Brehm, and R. Hillenbrand, "Substrate-enhanced infrared near-field spectroscopy," Opt. Express 16, 1529-1545 (2008). [CrossRef] [PubMed]
  13. U. Merker, P. Engels, F. Madeja, M. Havenith, and W. Urban, "High-resolution CO-laser sideband spectrometer for molecular-beam optothermal spectroscopy in the 5-6.6 ?m wavelength region," Rev. Sci. Instrum. 70, 1933-1938 (1999). [CrossRef]
  14. I. Kopf, J. S. Samson, G. Wollny, Ch. Grunwald, E. Bründermann, and M. Havenith, "Chemical imaging of microstructured self-assembled monolayers with nanometer resolution," J. Phys. Chem. C 111, 8166-8171 (2007). [CrossRef]
  15. Z. Arsov and L. Quaroni, "Direct interaction between cholesterol and phosphatidylcholines in hydrated membranes revealed by ATR-FTIR spectroscopy," Chem. Phys. Lipids 150, 35-48 (2007). [CrossRef] [PubMed]
  16. T. Buffeteau, B. Desbat, and D. Eyquem, "Attenuated total reflection Fourier transform infrared microspectroscopy: Theory and application to polymer samples," Vib. Spectrosc. 11, 29-36 (1996). [CrossRef]
  17. F. Picard, T. Buffeteau, B. Desbat, M. Auger, and M. Pézolet, "Quantitative orientation measurements in thin lipid films by attenuated total reflection infrared spectroscopy," Biophys. J. 76, 539-551 (1999). [CrossRef]
  18. N. Ocelic, A. J. Huber, and R. Hillenbrand, "Pseudoheterodyne detection for background-free near-field spectroscopy," Appl. Phys. Lett. 89, 101124-1-101124-3 (2006). [CrossRef]
  19. I. Horcas, R. Fernandez, J. M. Gomez-Rodriguez, J. Colchero, J. Gomez-Herrero, and A. M. Baro, "WSxM: A software for scanning probe microscopy and a tool for nanotechnology," Rev. Sci. Instrum. 78, 013705-1-013705-8 (2007). [CrossRef] [PubMed]
  20. B. Knoll and F. Keilmann, "Near-field probing of vibrational absorption for chemical microscopy," Nature 399, 134-137 (1999). [CrossRef]
  21. A. J. Guarino, T. N. Tulenko, and S. P. Wrenn, "Cholesterol crystal nucleation from enzymatically modified lowdensity lipoproteins: Combined effect of sphingomyelinase and cholesterol esterase," Biochemistry 43, 1685-1693 (2004). [CrossRef] [PubMed]

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