Assessment of arterial characteristics in human
atherosclerosis by extracting optical properties
from polarization-sensitive optical coherence
tomography

doi:10.1364/OE.16.008117

Assessment of arterial characteristics in human atherosclerosis by extracting optical properties from polarization-sensitive optical coherence tomography

Wen-Chuan Kuo, Ming-Wei Hsiung, Jeou-Jong Shyu, Nai-Kuan Chou, and Po-Nien Yang »View Author Affiliations

Optics Express, Vol. 16, Issue 11, pp. 8117-8125 (2008)
http://dx.doi.org/10.1364/OE.16.008117

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Abstract

In this research, we assessed arterial characteristics in human atherosclerosis by determining both scattering and birefringence properties of vessel tissue from polarization-sensitive optical coherence tomography (PS-OCT) images. We demonstrated that optical characteristics including scattering coefficient (µ_s), effective anisotropy factor (g _eff ), birefringence coefficient (Δn), and fast-axis angle (Β) of normal and different kinds of atherosclerotic lesions in human vessels can be quantitatively described. Based on our findings, a quantitative PS-OCT image criterion for plaque characterization was constructed.

OCIS Codes
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(260.5430) Physical optics : Polarization

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: March 20, 2008
Revised Manuscript: May 17, 2008
Manuscript Accepted: May 17, 2008
Published: May 20, 2008

Virtual Issues
Vol. 3, Iss. 6 Virtual Journal for Biomedical Optics

Citation
Wen-Chuan Kuo, Ming-Wei Hsiung, Jeou-Jong Shyu, Nai-Kuan Chou, and Po-Nien Yang, "Assessment of arterial characteristics in human atherosclerosis by extracting optical properties from polarization-sensitive optical coherence tomography," Opt. Express 16, 8117-8125 (2008)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-16-11-8117

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References

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R Hee, T. Flotte, K. Gregory, C. A. Pufialito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991). [CrossRef] [PubMed]
M. E. Brezinski, G. J. Tearney, B. E. Bouma, J. A. Izatt, M. R. Hee, E. A. Swanson, J. F. Southern, and J. G. Fujimoto, "Optical coherence tomography for optical biopsy: properties and demonstration of vascular pathology," Circulation 93, 1206-1213 (1996). [PubMed]
J. G. Fujimoto, M. E. Bresinski, G. J. Tearney, S. A. Boppart, B. E. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson, "Optical biopsy and imaging using optical coherence tomography," Nat. Med. 1, 970-972 (1995). [CrossRef] [PubMed]
M. E. Bresinski, G. J. Tearney, N. J. Weissman, S. A. Boppart, B. E. Bouma, M. R. Hee, A. E. Weyman, E. A. Swanson, J. F. Southern, and J. G. Fujimoto, "Assessing atherosclerotic plaque morphology: comparison of optical coherence tomography and high frequency intravascular ultrasound," Heart 77, 397-403 (1997).
H. Yabushita, B. E. Bouma, S. L. Houser, H. T. Aretz, I. K. Jang, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, D. H. Kang, E. F. Halpern, and G. J. Tearney, "Characterization of human atherosclerosis by optical coherence tomography," Circulation 106, 1640-1645 (2002). [CrossRef] [PubMed]
I. K. Jang, B. E. Bouma, D. H. Kang, S. J. Park, S. W. Park, K. B. Seung, K. B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S. L. Houser, H. T. Aretz, and G. J. Tearney, "Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound," J. Am. Coll. Cardiol. 39, 604-609 (2002). [CrossRef] [PubMed]
D. Stamper, N. J. Weissman, M. Brezinski, "Plaque characterization with optical coherence tomography," J. Am. Coll. Cardiol. 47, C69-C79 (2006). [CrossRef] [PubMed]
G. J. Tearney, I-K Jang, B. E. Bouma, "Optical coherence tomography for imaging the vulnerable plaque," J. Biomed. Opt. 11, 021002 (2006). [CrossRef] [PubMed]
G. J. Tearney, H. Yabushita, S. L. Houser, H. T. Aretz, I. K. Janf, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, E. F. Halpern, and B. E. Bouma, "Quantification of macrophage content in atherosclerotic plaques by optical coherence tomography," Circulation 107, 113-119 (2003). [CrossRef] [PubMed]
W. C. Kuo, J. J. Shyu, N. K. Chou, C. M. Lai, H. C. Huang, C. Chou, G. J. Jan, "Imaging of Human Aortic Atherosclerotic plaques by Polarization-Sensitive Optical Coherence Tomography," in Proceedings of IEEE Conference on Engineering in Medicine and Biology (San Francisco, 2004), pp. 1111-1114.
W. C. Kuo, J. J. Shyu, N. K. Chou, C. M. Lai, E. K. Tien, H. J. Huang, C. Chou, and G. J. Jan, "Correlation of collagen synthesis with polarization-sensitive optical coherence tomography imaging of in vitro human atherosclerosis," Proc. SPIE 5690, 563-571 (2005). [CrossRef]
S. D. Giattina, B. K. Courtney, P. R. Herz, M. Harman, S. Shortkroff, D. L. Stamper, B. Liu, J. G. Fujimoto, M. E. Brezinski, "Assessment of coronary plaque collagen with polarization sensitive optical coherence tomography (PS-OCT)," Int. J. Cardiol. 107, 400-409 (2006). [CrossRef] [PubMed]
S. K. Nadkarni, M. C. Pierce, B. H. Park, J. F. de Boer, P. Whittaker, B. E. Bouma, J. E. Bressner, E. Halpern, S. L. Houser, and G. J. Teaeney, "Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization sensitive optical coherence tomography," J. Am. Coll. Cardiol. 49, 1474-1481 (2007). [CrossRef] [PubMed]
W. C. Kuo, N. K. Chou, C. Chou, C. M. Lai, H. J. Huang, and J. J. Shyu, "Polarization-sensitive optical coherence tomography for imaging human atherosclerosis," Appl. Opt. 46, 2520-2527 (2007). [CrossRef] [PubMed]
W. C. Kuo, M. W. Hsiung, and P. N. Yang, "Extracting quantitative optical properties of human vessel from PS-OCT images," Med. Biol. Eng. 27, 191-197 (2007).
W. C. Kuo, M. W. Hsiung, J. J. Shyu, N. K. Chou, and P. N. Yang, "Quantitative analysis on optical properties of human atherosclerosis by using polarization-sensitive optical coherence tomography," Proc. SPIE 6842, 684223-1-6842323-9 (2008). [CrossRef]
L. Thrane, H. T. Yura, and P. E. Andersen, "Analysis of optical coherence tomography systems based on the extended Huygens-Fresenel principle," J. Opt. Soc. Am. A 17, 484-490 (2000). [CrossRef]
D. Levitz, L. Thrane, M. H. Frosz, P. E. Andersen, C. B. Andersen, J. Valanciunaite, J. Swartling, S. Andersson-Engels and P. R. Hansen, "Determination of optical properties of highly-scattering media in optical coherence tomography," Opt. Express 12, 249-259 (2004). [CrossRef] [PubMed]
C. E. Metz, "Basic principles of ROC analysis," Semin. Nucl. Med. 8, 283-298 (1978). [CrossRef] [PubMed]

Andersen, C. B.
Andersen, P. E.
Andersson-Engels, S.
Aretz, H. T.
Boppart, S. A.
Bouma, B. E.
Bresinski, M. E.
Bressner, J. E.
Brezinski, M.
Brezinski, M. E.
Chang, W.
Choi, K. B.
Chou, C.
Chou, N. K.
Courtney, B. K.
de Boer, J. F.
Flotte, T.
Frosz, M. H.
Fujimoto, J. G.
Giattina, S. D.
Gregory, K.
Halpern, E.
Halpern, E. F.
Hansen, P. R.
Harman, M.
Hee, M. R
Hee, M. R.
Herz, P. R.
Houser, S. L.
Hsiung, M. W.
Huang, D.
Huang, H. J.
Izatt, J. A.
Jan, G. J.
Janf, I. K.
Jang, I. K.
Jang, I-K
Kang, D. H.
Kauffman, C. R.
Kuo, W. C.
Lai, C. M.
Levitz, D.
Lin, C. P.
Liu, B.
Metz, C. E.
Nadkarni, S. K.
Park, B. H.
Park, S. J.
Park, S. W.
Pierce, M. C.
Pomerantsev, E.
Pufialito, C. A.
Schlendorf, K.
Schlendorf, K. H.
Schuman, J. S.
Seung, K. B.
Shishkov, M.
Shortkroff, S.
Shyu, J. J.
Southern, J. F.
Stamper, D.
Stamper, D. L.
Stinson, W. G.
Swanson, E. A.
Swartling, J.
Teaeney, G. J.
Tearney, G. J.
Thrane, L.
Tien, E. K.
Valanciunaite, J.
Weissman, N. J.
Weyman, A. E.
Whittaker, P.
Yabushita, H.
Yang, P. N.
Yura, H. T.

Appl. Opt.

W. C. Kuo, N. K. Chou, C. Chou, C. M. Lai, H. J. Huang, and J. J. Shyu, "Polarization-sensitive optical coherence tomography for imaging human atherosclerosis," Appl. Opt. 46, 2520-2527 (2007). [CrossRef] [PubMed]

Circulation

G. J. Tearney, H. Yabushita, S. L. Houser, H. T. Aretz, I. K. Janf, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, E. F. Halpern, and B. E. Bouma, "Quantification of macrophage content in atherosclerotic plaques by optical coherence tomography," Circulation 107, 113-119 (2003). [CrossRef] [PubMed]
M. E. Brezinski, G. J. Tearney, B. E. Bouma, J. A. Izatt, M. R. Hee, E. A. Swanson, J. F. Southern, and J. G. Fujimoto, "Optical coherence tomography for optical biopsy: properties and demonstration of vascular pathology," Circulation 93, 1206-1213 (1996). [PubMed]
H. Yabushita, B. E. Bouma, S. L. Houser, H. T. Aretz, I. K. Jang, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, D. H. Kang, E. F. Halpern, and G. J. Tearney, "Characterization of human atherosclerosis by optical coherence tomography," Circulation 106, 1640-1645 (2002). [CrossRef] [PubMed]

Heart

M. E. Bresinski, G. J. Tearney, N. J. Weissman, S. A. Boppart, B. E. Bouma, M. R. Hee, A. E. Weyman, E. A. Swanson, J. F. Southern, and J. G. Fujimoto, "Assessing atherosclerotic plaque morphology: comparison of optical coherence tomography and high frequency intravascular ultrasound," Heart 77, 397-403 (1997).

Int. J. Cardiol.

S. D. Giattina, B. K. Courtney, P. R. Herz, M. Harman, S. Shortkroff, D. L. Stamper, B. Liu, J. G. Fujimoto, M. E. Brezinski, "Assessment of coronary plaque collagen with polarization sensitive optical coherence tomography (PS-OCT)," Int. J. Cardiol. 107, 400-409 (2006). [CrossRef] [PubMed]

J. Am. Coll. Cardiol.

S. K. Nadkarni, M. C. Pierce, B. H. Park, J. F. de Boer, P. Whittaker, B. E. Bouma, J. E. Bressner, E. Halpern, S. L. Houser, and G. J. Teaeney, "Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization sensitive optical coherence tomography," J. Am. Coll. Cardiol. 49, 1474-1481 (2007). [CrossRef] [PubMed]
I. K. Jang, B. E. Bouma, D. H. Kang, S. J. Park, S. W. Park, K. B. Seung, K. B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S. L. Houser, H. T. Aretz, and G. J. Tearney, "Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound," J. Am. Coll. Cardiol. 39, 604-609 (2002). [CrossRef] [PubMed]
D. Stamper, N. J. Weissman, M. Brezinski, "Plaque characterization with optical coherence tomography," J. Am. Coll. Cardiol. 47, C69-C79 (2006). [CrossRef] [PubMed]

J. Biomed. Opt.

G. J. Tearney, I-K Jang, B. E. Bouma, "Optical coherence tomography for imaging the vulnerable plaque," J. Biomed. Opt. 11, 021002 (2006). [CrossRef] [PubMed]

J. Opt. Soc. Am. A

L. Thrane, H. T. Yura, and P. E. Andersen, "Analysis of optical coherence tomography systems based on the extended Huygens-Fresenel principle," J. Opt. Soc. Am. A 17, 484-490 (2000). [CrossRef]

Med. Biol. Eng.

W. C. Kuo, M. W. Hsiung, and P. N. Yang, "Extracting quantitative optical properties of human vessel from PS-OCT images," Med. Biol. Eng. 27, 191-197 (2007).

Nat. Med.

J. G. Fujimoto, M. E. Bresinski, G. J. Tearney, S. A. Boppart, B. E. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson, "Optical biopsy and imaging using optical coherence tomography," Nat. Med. 1, 970-972 (1995). [CrossRef] [PubMed]

Opt. Express

D. Levitz, L. Thrane, M. H. Frosz, P. E. Andersen, C. B. Andersen, J. Valanciunaite, J. Swartling, S. Andersson-Engels and P. R. Hansen, "Determination of optical properties of highly-scattering media in optical coherence tomography," Opt. Express 12, 249-259 (2004). [CrossRef] [PubMed]

Proc. SPIE

W. C. Kuo, J. J. Shyu, N. K. Chou, C. M. Lai, E. K. Tien, H. J. Huang, C. Chou, and G. J. Jan, "Correlation of collagen synthesis with polarization-sensitive optical coherence tomography imaging of in vitro human atherosclerosis," Proc. SPIE 5690, 563-571 (2005). [CrossRef]

Science

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R Hee, T. Flotte, K. Gregory, C. A. Pufialito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991). [CrossRef] [PubMed]

Semin. Nucl. Med.

C. E. Metz, "Basic principles of ROC analysis," Semin. Nucl. Med. 8, 283-298 (1978). [CrossRef] [PubMed]

Other

W. C. Kuo, M. W. Hsiung, J. J. Shyu, N. K. Chou, and P. N. Yang, "Quantitative analysis on optical properties of human atherosclerosis by using polarization-sensitive optical coherence tomography," Proc. SPIE 6842, 684223-1-6842323-9 (2008). [CrossRef]
W. C. Kuo, J. J. Shyu, N. K. Chou, C. M. Lai, H. C. Huang, C. Chou, G. J. Jan, "Imaging of Human Aortic Atherosclerotic plaques by Polarization-Sensitive Optical Coherence Tomography," in Proceedings of IEEE Conference on Engineering in Medicine and Biology (San Francisco, 2004), pp. 1111-1114.

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[1] D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R Hee, T. Flotte, K. Gregory, C. A. Pufialito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991). [CrossRef] [PubMed]

[2] M. E. Brezinski, G. J. Tearney, B. E. Bouma, J. A. Izatt, M. R. Hee, E. A. Swanson, J. F. Southern, and J. G. Fujimoto, "Optical coherence tomography for optical biopsy: properties and demonstration of vascular pathology," Circulation 93, 1206-1213 (1996). [PubMed]

[3] J. G. Fujimoto, M. E. Bresinski, G. J. Tearney, S. A. Boppart, B. E. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson, "Optical biopsy and imaging using optical coherence tomography," Nat. Med. 1, 970-972 (1995). [CrossRef] [PubMed]

[4] M. E. Bresinski, G. J. Tearney, N. J. Weissman, S. A. Boppart, B. E. Bouma, M. R. Hee, A. E. Weyman, E. A. Swanson, J. F. Southern, and J. G. Fujimoto, "Assessing atherosclerotic plaque morphology: comparison of optical coherence tomography and high frequency intravascular ultrasound," Heart 77, 397-403 (1997).

[5] H. Yabushita, B. E. Bouma, S. L. Houser, H. T. Aretz, I. K. Jang, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, D. H. Kang, E. F. Halpern, and G. J. Tearney, "Characterization of human atherosclerosis by optical coherence tomography," Circulation 106, 1640-1645 (2002). [CrossRef] [PubMed]

[6] I. K. Jang, B. E. Bouma, D. H. Kang, S. J. Park, S. W. Park, K. B. Seung, K. B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S. L. Houser, H. T. Aretz, and G. J. Tearney, "Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound," J. Am. Coll. Cardiol. 39, 604-609 (2002). [CrossRef] [PubMed]

[7] D. Stamper, N. J. Weissman, M. Brezinski, "Plaque characterization with optical coherence tomography," J. Am. Coll. Cardiol. 47, C69-C79 (2006). [CrossRef] [PubMed]

[8] G. J. Tearney, I-K Jang, B. E. Bouma, "Optical coherence tomography for imaging the vulnerable plaque," J. Biomed. Opt. 11, 021002 (2006). [CrossRef] [PubMed]

[9] G. J. Tearney, H. Yabushita, S. L. Houser, H. T. Aretz, I. K. Janf, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, E. F. Halpern, and B. E. Bouma, "Quantification of macrophage content in atherosclerotic plaques by optical coherence tomography," Circulation 107, 113-119 (2003). [CrossRef] [PubMed]

[10] W. C. Kuo, J. J. Shyu, N. K. Chou, C. M. Lai, H. C. Huang, C. Chou, G. J. Jan, "Imaging of Human Aortic Atherosclerotic plaques by Polarization-Sensitive Optical Coherence Tomography," in Proceedings of IEEE Conference on Engineering in Medicine and Biology (San Francisco, 2004), pp. 1111-1114.

[11] W. C. Kuo, J. J. Shyu, N. K. Chou, C. M. Lai, E. K. Tien, H. J. Huang, C. Chou, and G. J. Jan, "Correlation of collagen synthesis with polarization-sensitive optical coherence tomography imaging of in vitro human atherosclerosis," Proc. SPIE 5690, 563-571 (2005). [CrossRef]

[12] S. D. Giattina, B. K. Courtney, P. R. Herz, M. Harman, S. Shortkroff, D. L. Stamper, B. Liu, J. G. Fujimoto, M. E. Brezinski, "Assessment of coronary plaque collagen with polarization sensitive optical coherence tomography (PS-OCT)," Int. J. Cardiol. 107, 400-409 (2006). [CrossRef] [PubMed]

[13] S. K. Nadkarni, M. C. Pierce, B. H. Park, J. F. de Boer, P. Whittaker, B. E. Bouma, J. E. Bressner, E. Halpern, S. L. Houser, and G. J. Teaeney, "Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization sensitive optical coherence tomography," J. Am. Coll. Cardiol. 49, 1474-1481 (2007). [CrossRef] [PubMed]

[14] W. C. Kuo, N. K. Chou, C. Chou, C. M. Lai, H. J. Huang, and J. J. Shyu, "Polarization-sensitive optical coherence tomography for imaging human atherosclerosis," Appl. Opt. 46, 2520-2527 (2007). [CrossRef] [PubMed]

[15] W. C. Kuo, M. W. Hsiung, and P. N. Yang, "Extracting quantitative optical properties of human vessel from PS-OCT images," Med. Biol. Eng. 27, 191-197 (2007).

[16] W. C. Kuo, M. W. Hsiung, J. J. Shyu, N. K. Chou, and P. N. Yang, "Quantitative analysis on optical properties of human atherosclerosis by using polarization-sensitive optical coherence tomography," Proc. SPIE 6842, 684223-1-6842323-9 (2008). [CrossRef]

[17] L. Thrane, H. T. Yura, and P. E. Andersen, "Analysis of optical coherence tomography systems based on the extended Huygens-Fresenel principle," J. Opt. Soc. Am. A 17, 484-490 (2000). [CrossRef]

[18] D. Levitz, L. Thrane, M. H. Frosz, P. E. Andersen, C. B. Andersen, J. Valanciunaite, J. Swartling, S. Andersson-Engels and P. R. Hansen, "Determination of optical properties of highly-scattering media in optical coherence tomography," Opt. Express 12, 249-259 (2004). [CrossRef] [PubMed]

[19] C. E. Metz, "Basic principles of ROC analysis," Semin. Nucl. Med. 8, 283-298 (1978). [CrossRef] [PubMed]

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