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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 16, Iss. 14 — Jul. 7, 2008
  • pp: 10214–10219

Temporal statistical analysis of laser speckle images and its application to retinal blood-flow imaging

Haiying Cheng, Yumei Yan, and Timothy Q. Duong  »View Author Affiliations

Optics Express, Vol. 16, Issue 14, pp. 10214-10219 (2008)

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Temporal-statistical analysis of laser-speckle image (TS-LSI) preserves the original spatial resolution, in contrast to conventional spatialstatistical analysis (SS-LSI). Concerns have been raised regarding the temporal independency of TS-LSI signals and its insensitivity toward stationary-speckle contamination. Our results from flow phantoms and in vivo rat retinas demonstrated that the TS-LSI signals are temporally statistically independent and TS-LSI minimizes stationary-speckle contamination. The latter is because the stationary speckle is “non-random” and thus non-ergodic where the temporal average of stationary speckle needs not equal its spatial ensemble average. TS-LSI detects blood flow in smaller blood vessels and is less susceptible to stationary-speckle artifacts.

© 2008 Optical Society of America

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4470) Medical optics and biotechnology : Ophthalmology
(170.6480) Medical optics and biotechnology : Spectroscopy, speckle

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: April 25, 2008
Revised Manuscript: June 16, 2008
Manuscript Accepted: June 18, 2008
Published: June 24, 2008

Virtual Issues
Vol. 3, Iss. 8 Virtual Journal for Biomedical Optics

Haiying Cheng, Yumei Yan, and Timothy Q. Duong, "Temporal statistical analysis of laser speckle images and its application to retinal blood-flow imaging," Opt. Express 16, 10214-10219 (2008)

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