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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 16, Iss. 14 — Jul. 7, 2008
  • pp: 10279–10284

In vivo burn imaging using Mueller optical coherence tomography

Miloš Todorović, Shuliang Jiao, Jun Ai, David Pereda-Cubián, George Stoica, and Lihong V. Wang  »View Author Affiliations

Optics Express, Vol. 16, Issue 14, pp. 10279-10284 (2008)

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We report on the use of a high-speed, fiber-based Mueller-matrix optical coherence tomography system with continuous source-polarization modulation for in vivo burn depth evaluation and healing monitoring. A homemade hand-held probe with integrated optical scanning and beam delivering optics was coupled in the sample arm. In vivo burn imaging was demonstrated on porcine skin at different stages of the wound healing process, where porcine skin was used because of its similarity to the human skin. Thermally damaged region was clearly localized in the depth-resolved phase retardation image extracted from the measured Jones matrix. The burn areas in the OCT images agreed well with the histology. By using a decomposition algorithm developed by our group, we also mapped the local birefringence of the skin. The experimental results demonstrate the system’s potential for in vivo burn-depth determination.

© 2008 Optical Society of America

OCIS Codes
(170.1650) Medical optics and biotechnology : Coherence imaging
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(260.1440) Physical optics : Birefringence
(260.5430) Physical optics : Polarization
(290.7050) Scattering : Turbid media

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: March 7, 2008
Revised Manuscript: May 16, 2008
Manuscript Accepted: May 16, 2008
Published: June 26, 2008

Virtual Issues
Vol. 3, Iss. 8 Virtual Journal for Biomedical Optics

Miloš Todorovic, Shuliang Jiao, Jun Ai, David Pereda-Cubián, George Stoica, and Lihong V. Wang, "In vivo burn imaging using Mueller optical coherence tomography," Opt. Express 16, 10279-10284 (2008)

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