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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 16, Iss. 15 — Jul. 21, 2008
  • pp: 11052–11065

Optical micro-scale mapping of dynamic biomechanical tissue properties

Xing Liang, Amy L. Oldenburg, Vasilica Crecea, Eric J. Chaney, and Stephen A. Boppart  »View Author Affiliations


Optics Express, Vol. 16, Issue 15, pp. 11052-11065 (2008)
http://dx.doi.org/10.1364/OE.16.011052


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Abstract

Mechanical forces such as adhesion, shear stress and compression play crucial roles in tissue growth, patterning and development. To understand the role of these mechanical stimuli, it is of great importance to measure biomechanical properties of developing, engineered, and natural tissues. To enable these measurements on the micro-scale, a novel, dynamic, non-invasive, high-speed optical coherence elastography (OCE) system has been developed utilizing spectral-domain optical coherence tomography (OCT) and a mechanical wave driver. Experimental results of OCE on silicone phantoms are in good agreement with those obtained from a standardized indentation method. Using phase-resolved imaging, we demonstrate OCE can map dynamic elastic moduli of normal and neoplastic ex vivo human breast tissue with a sensitivity of 0.08%. Spatial micro-scale mapping of elastic moduli of tissue offers the potential for basic science and clinical investigations into the role biomechanics play in health and disease.

© 2008 Optical Society of America

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(120.5050) Instrumentation, measurement, and metrology : Phase measurement
(120.5820) Instrumentation, measurement, and metrology : Scattering measurements
(170.6935) Medical optics and biotechnology : Tissue characterization

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: May 8, 2008
Revised Manuscript: June 27, 2008
Manuscript Accepted: July 3, 2008
Published: July 9, 2008

Virtual Issues
Vol. 3, Iss. 8 Virtual Journal for Biomedical Optics

Citation
Xing Liang, Amy L. Oldenburg, Vasilica Crecea, Eric J. Chaney, and Stephen A. Boppart, "Optical micro-scale mapping of dynamic biomechanical tissue properties," Opt. Express 16, 11052-11065 (2008)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-16-15-11052


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