Algorithm and simulation for analysis of bio-images obtained by aperture diffraction based optical MEMS

doi:10.1364/OE.16.011937

Algorithm and simulation for analysis of bio-images obtained by aperture diffraction based optical MEMS

Xiaodong Zhou, Daniel Puiu Poenar, Kai Yu Liu, Man Siu Tse, Chew-Kiat Heng, Swee Ngin Tan, and Nan Zhang »View Author Affiliations

Optics Express, Vol. 16, Issue 16, pp. 11937-11953 (2008)
http://dx.doi.org/10.1364/OE.16.011937

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Abstract
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Abstract

This paper proposes a novel method to detect transparent living cells in a transparent microfluidic chamber by optical diffraction of an aperture or an aperture array. Through the analysis of the far-field diffraction pattern, one of the parameters of the cells, including the size, refractive index, or position, can be extracted by the analysis software developed in this paper. Calculations are carried out to discuss the key issues of this MEMS device, and our simulation is verified by diffraction patterns of transparent microparticles on fabricated apertures, recorded via a digital camera

OCIS Codes
(050.1970) Diffraction and gratings : Diffractive optics
(230.4000) Optical devices : Microstructure fabrication

ToC Category:
Diffraction and Gratings

History
Original Manuscript: May 28, 2008
Revised Manuscript: July 22, 2008
Manuscript Accepted: July 22, 2008
Published: July 25, 2008

Virtual Issues
Vol. 3, Iss. 9 Virtual Journal for Biomedical Optics

Citation
Xiaodong Zhou, Daniel Puiu Poenar, Kai Yu Liu, Man Siu Tse, Chew-Kiat Heng, Swee Ngin Tan, and Nan Zhang, "Algorithm and simulation for analysis of bio-images obtained by aperture diffraction based optical MEMS," Opt. Express 16, 11937-11953 (2008)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-16-16-11937

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References

J. James and H. J. Tanke, Biomedical Light Microscopy (Kluwer Academic Publishers, 1991). [CrossRef]
M. Pluta, Advanced Light Microscopy Vol. 2. Specialized Methods (PWN-Polish Scientific Publishers, Warszawa, Poland, 1988).
K. Chen, A. Kromin, M.P. Ulmer, B.W. Wessels, and V. Backman, "Nanoparticle sizing with a resolution beyond the diffraction limit using UV light scattering spectroscopy," Opt. Commun. 228, 1-7 (2003). [CrossRef]
S. C. Hill, R. G. Pinnick, P. Nachman, G. Chen, R. K. Chang, M. W. Mayo, and G. L. Fernandez, "Aerosol-fluorescence spectrum analyzer: real-time measurement of emission spectra of airborne biological particles," Appl. Opt. 34, 7149-7155 (1995). [CrossRef] [PubMed]
Y. Yang, Z. Zhang, X. Yang, J. H. Yeo, L. Jiang, and D. Jiang, "Blood cell counting and classification by nonflowing laser light scattering method," J. Biomed. Opt. 9, 995-1001 (2004). [CrossRef] [PubMed]
A. Katz, A. Alimova, M. Xu, E. Rudolph, M. K. Shah, H. E. Savage, R. B. Rosen, S. A. McCormick, and R. R. Alfano, "Bacteria size determination by elastic light scattering," IEEE J. Sel. Top. Quantum Electron. 9, 277-287 (2003). [CrossRef]
F. Morhard, J. Pipper, R. Dahint, and M. Grunze, "Immobilization of antibodies in micropatterns for cell detection by optical diffraction," Sens. Actuatuators B. 70, 232-242 (2000). [CrossRef]
G. T. Williams, R. D. Bahuguna, H. Arteaga, and E. N. Le Joie, "Study of microbial growth I: By diffraction," Proc. SPIE 1332, 802-804 (1991). [CrossRef]
P. M. St. John, R. Davis, N. Cady, J. Czajka, C. A. Batt, and H. G. Craighead, "Diffraction-based cell detection using a microcontact printed antibody grating," Anal. Chem. 70, 1108-1111 (1998). [CrossRef]
F. D. King and S. E. Leblanc, "Method and Apparatus for particle measurement employing optical imaging," CA2487233 (2005).
M. Born and E. Wolf, Principles of Optics (Cambridge University Press, 1999).

Anal. Chem.

P. M. St. John, R. Davis, N. Cady, J. Czajka, C. A. Batt, and H. G. Craighead, "Diffraction-based cell detection using a microcontact printed antibody grating," Anal. Chem. 70, 1108-1111 (1998). [CrossRef]

Appl. Opt.

S. C. Hill, R. G. Pinnick, P. Nachman, G. Chen, R. K. Chang, M. W. Mayo, and G. L. Fernandez, "Aerosol-fluorescence spectrum analyzer: real-time measurement of emission spectra of airborne biological particles," Appl. Opt. 34, 7149-7155 (1995). [CrossRef] [PubMed]

IEEE J. Sel. Top. Quantum Electron.

A. Katz, A. Alimova, M. Xu, E. Rudolph, M. K. Shah, H. E. Savage, R. B. Rosen, S. A. McCormick, and R. R. Alfano, "Bacteria size determination by elastic light scattering," IEEE J. Sel. Top. Quantum Electron. 9, 277-287 (2003). [CrossRef]

J. Biomed. Opt.

Y. Yang, Z. Zhang, X. Yang, J. H. Yeo, L. Jiang, and D. Jiang, "Blood cell counting and classification by nonflowing laser light scattering method," J. Biomed. Opt. 9, 995-1001 (2004). [CrossRef] [PubMed]

Opt. Commun.

K. Chen, A. Kromin, M.P. Ulmer, B.W. Wessels, and V. Backman, "Nanoparticle sizing with a resolution beyond the diffraction limit using UV light scattering spectroscopy," Opt. Commun. 228, 1-7 (2003). [CrossRef]

Proc. SPIE

G. T. Williams, R. D. Bahuguna, H. Arteaga, and E. N. Le Joie, "Study of microbial growth I: By diffraction," Proc. SPIE 1332, 802-804 (1991). [CrossRef]

Sens. Actuatuators B.

F. Morhard, J. Pipper, R. Dahint, and M. Grunze, "Immobilization of antibodies in micropatterns for cell detection by optical diffraction," Sens. Actuatuators B. 70, 232-242 (2000). [CrossRef]

Other

J. James and H. J. Tanke, Biomedical Light Microscopy (Kluwer Academic Publishers, 1991). [CrossRef]
M. Pluta, Advanced Light Microscopy Vol. 2. Specialized Methods (PWN-Polish Scientific Publishers, Warszawa, Poland, 1988).
F. D. King and S. E. Leblanc, "Method and Apparatus for particle measurement employing optical imaging," CA2487233 (2005).
M. Born and E. Wolf, Principles of Optics (Cambridge University Press, 1999).

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