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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 16, Iss. 18 — Sep. 1, 2008
  • pp: 13643–13650

Fast time-domain diffuse optical tomography using pseudorandom bit sequences

Weirong Mo and Nanguang Chen  »View Author Affiliations

Optics Express, Vol. 16, Issue 18, pp. 13643-13650 (2008)

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We report a novel time-domain diffuse optical tomography to determine the optical properties in a faster speed than the conventional ones. Instead of using the ultrashort pulse laser, a 2.5 Gbps pseudorandom bit sequence is used to modulate the near-infrared light for tissue-like phantom illumination. The time-resolved signal can be retrieved very quickly by demodulation with the reference signal. The system impulse response has a full width at half maximum around 800 picoseconds and the 2-dimentional maps of optical properties can be obtained within a few seconds. The high signal-to-noise ratio and the environmental illumination insensitivity warrant a great potential for applications in clinical noninvasive breast cancer detection.

© 2008 Optical Society of America

OCIS Codes
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.5280) Medical optics and biotechnology : Photon migration
(170.6920) Medical optics and biotechnology : Time-resolved imaging
(170.6960) Medical optics and biotechnology : Tomography

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: June 23, 2008
Revised Manuscript: August 12, 2008
Manuscript Accepted: August 18, 2008
Published: August 20, 2008

Virtual Issues
Vol. 3, Iss. 11 Virtual Journal for Biomedical Optics

Weirong Mo and Nanguang Chen, "Fast time-domain diffuse optical tomography using pseudorandom bit sequences," Opt. Express 16, 13643-13650 (2008)

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