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Optics Express

Optics Express

  • Editor: Martijn de Sterke
  • Vol. 16, Iss. 20 — Sep. 29, 2008
  • pp: 15847–15862

Effective indicators for diagnosis of oral cancer using optical coherence tomography

Meng-Tsan Tsai, Hsiang-Chieh Lee, Cheng-Kuang Lee, Chuan-Hang Yu, Hsin-Ming Chen, Chun-Pin Chiang, Cheng-Chang Chang, Yih-Ming Wang, and C. C. Yang  »View Author Affiliations

Optics Express, Vol. 16, Issue 20, pp. 15847-15862 (2008)

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A swept-source optical coherence tomography system is used to clinically scan oral precancer and cancer patients for statistically analyzing the effective indicators of diagnosis. Three indicators are considered, including the standard deviation (SD) of an A-mode scan signal profile, the exponential decay constant (α) of an A-mode-scan spatial-frequency spectrum, and the epithelium thickness (T) when the boundary between epithelium and lamina propria can still be identified. Generally, in abnormal mucosa, the standard deviation becomes larger, the decay constant of the spatial-frequency spectrum becomes smaller, and epithelium becomes thicker. The sensitivity and specificity of the three indicators are discussed based on universal and individual relative criteria. It is found that SD and α are good diagnosis indicators for moderate dysplasia and squamous cell carcinoma. On the other hand, T is a good diagnosis indicator for epithelia hyperplasia and moderate dysplasia.

© 2008 Optical Society of America

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(170.3880) Medical optics and biotechnology : Medical and biological imaging

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: June 10, 2008
Revised Manuscript: September 7, 2008
Manuscript Accepted: September 16, 2008
Published: September 22, 2008

Virtual Issues
Vol. 3, Iss. 11 Virtual Journal for Biomedical Optics

C. C. Yang, Meng-Tsan Tsai, Hsiang-Chieh Lee, Cheng-Kuang Lee, Chuan-Hang Yu, Hsin-Ming Chen, Chun-Pin Chiang, Cheng-Chang Chang, Yih-Ming Wang, and C. C. Yang, "Effective indicators for diagnosis of oral cancer using optical coherence tomography," Opt. Express 16, 15847-15862 (2008)

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