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Optics Express

Optics Express

  • Editor: Martijn de Sterke
  • Vol. 16, Iss. 20 — Sep. 29, 2008
  • pp: 16227–16239

Quantitative spectroscopic imaging for noninvasive early cancer detection

Chung-Chieh Yu, Condon Lau, Geoff O’Donoghue, Jelena Mirkovic, Sasha McGee, Luis Galindo, Alphi Elackattu, Elizabeth Stier, Gregory Grillone, Kamran Badizadegan, Ramachandra R. Dasari, and Michael S. Feld  »View Author Affiliations

Optics Express, Vol. 16, Issue 20, pp. 16227-16239 (2008)

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We report a fully quantitative spectroscopy imaging instrument for wide area detection of early cancer (dysplasia). This instrument provides quantitative maps of tissue biochemistry and morphology, making it a potentially powerful surveillance tool for objective early cancer detection. We describe the design, construction, calibration, and first clinical application of this new system. We demonstrate its accuracy using physical tissue models. We validate its diagnostic ability on a resected colon adenoma, and demonstrate feasibility of in vivo imaging in the oral cavity.

© 2008 Optical Society of America

OCIS Codes
(170.0110) Medical optics and biotechnology : Imaging systems
(170.1610) Medical optics and biotechnology : Clinical applications
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(300.0300) Spectroscopy : Spectroscopy

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: July 25, 2008
Revised Manuscript: September 18, 2008
Manuscript Accepted: September 22, 2008
Published: September 26, 2008

Virtual Issues
Vol. 3, Iss. 11 Virtual Journal for Biomedical Optics

Chung-Chieh Yu, Condon Lau, Geoffrey O'Donoghue, Jelena Mirkovic, Sasha McGee, Luis Galindo, Alphi Elackattu, Elizabeth Stier, Gregory Grillone, Kamran Badizadegan, Ramachandra R. Dasari, and Michael S. Feld, "Quantitative spectroscopic imaging for non-invasive early cancer detection," Opt. Express 16, 16227-16239 (2008)

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