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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 16, Iss. 21 — Oct. 13, 2008
  • pp: 16410–16422

Retinal pigment epithelium segmentation by polarization sensitive optical coherence tomography

Erich Götzinger, Michael Pircher, Wolfgang Geitzenauer, Christian Ahlers, Bernhard Baumann, Stephan Michels, Ursula Schmidt-Erfurth, and Christoph K. Hitzenberger  »View Author Affiliations


Optics Express, Vol. 16, Issue 21, pp. 16410-16422 (2008)
http://dx.doi.org/10.1364/OE.16.016410


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Abstract

We present a new method for identifying and segmenting the retinal pigment epithelium (RPE) in polarization sensitive optical coherence tomography (PS-OCT) images of the human retina. Contrary to previous, intensity based segmentation algorithms, our method uses an intrinsic tissue property of the RPE: its depolarizing, or polarization scrambling effect on backscattered light. Two different segmentation algorithms are presented and discussed: a simpler algorithm based on retardation data, and a more sophisticated algorithm based on local variations of the polarization state calculated from averaged Stokes vector elements. By using a state of the art spectral domain PS-OCT instrument, we demonstrate the method in healthy and diseased eyes.

© 2008 Optical Society of America

OCIS Codes
(170.4470) Medical optics and biotechnology : Ophthalmology
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(230.5440) Optical devices : Polarization-selective devices

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: July 9, 2008
Revised Manuscript: September 26, 2008
Manuscript Accepted: September 26, 2008
Published: September 30, 2008

Virtual Issues
Vol. 3, Iss. 12 Virtual Journal for Biomedical Optics

Citation
Erich Götzinger, Michael Pircher, Wolfgang Geitzenauer, Christian Ahlers, Bernhard Baumann, Stephan Michels, Ursula Schmidt-Erfurth, and Christoph K. Hitzenberger, "Retinal pigment epithelium segmentation by polarization sensitive optical coherence tomography," Opt. Express 16, 16410-16422 (2008)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-16-21-16410


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