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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 16, Iss. 22 — Oct. 27, 2008
  • pp: 17505–17520

Trans-rectal ultrasound-coupled near-infrared optical tomography of the prostate Part II: Experimental demonstration

Zhen Jiang, Daqing Piao, Guan Xu, Jerry W. Ritchey, G. Reed Holyoak, Kenneth E. Bartels, Charles F. Bunting, Gennady Slobodov, and Jerzy S. Krasinki  »View Author Affiliations

Optics Express, Vol. 16, Issue 22, pp. 17505-17520 (2008)

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We demonstrate trans-rectal optical tomography of the prostate using an endo-rectal near-infrared (NIR) applicator integrated with a trans-rectal ultrasound (TRUS) probe. The endo-rectal NIR applicator incorporated a design presented in our previously reported work. A continuous-wave NIR optical tomography system is combined with a commercial US scanner to form the dual-modality imager. Sagittal trans-rectal imaging is performed concurrently by endo-rectal NIR and TRUS. The TRUS ensures accurate positioning of the NIR applicator as well as guides NIR image reconstruction using the spatial prior of the target. The use of a condom, which is standard for TRUS, is found to have minimal effect on trans-rectal NIR imaging. Tests on avian tissues validates that NIR imaging can recover the absorption contrast of a target, and its accuracy is improved when the TRUS spatial prior is incorporated. Trans-rectal NIR/US imaging of a healthy canine prostate in situ is reported.

© 2008 Optical Society of America

OCIS Codes
(170.1610) Medical optics and biotechnology : Clinical applications
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6960) Medical optics and biotechnology : Tomography
(170.7230) Medical optics and biotechnology : Urology

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: August 8, 2008
Revised Manuscript: October 13, 2008
Manuscript Accepted: October 14, 2008
Published: October 15, 2008

Virtual Issues
Vol. 3, Iss. 12 Virtual Journal for Biomedical Optics

Zhen Jiang, Daqing Piao, Guan Xu, Jerry W. Ritchey, G. R. Holyoak, Kenneth E. Bartels, Charles F. Bunting, Gennady Slobodov, and Jerzy S. Krasinski, "Trans-rectal ultrasound-coupled near-infrared optical tomography of the prostate, Part II: Experimental demonstration," Opt. Express 16, 17505-17520 (2008)

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