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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 16, Iss. 22 — Oct. 27, 2008
  • pp: 17667–17681

Depth dependence of estimated optical properties of a scattering inclusion by time-resolved contrast functions

Rosario Esposito, Sergio De Nicola, Marco Brambilla, Antonio Pifferi, Lorenzo Spinelli, and Maria Lepore  »View Author Affiliations


Optics Express, Vol. 16, Issue 22, pp. 17667-17681 (2008)
http://dx.doi.org/10.1364/OE.16.017667


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Abstract

In this study we have theoretically and experimentally investigated the behavior of first order approximation contrast function when purely scattering inhomogeneities located at different depths inside a turbid thick slab are considered. Results of model predictions have been compared with Finite element method simulations and tested on phantoms. To this aim, we have developed for the first time to our knowledge a fitting algorithm for estimating both the scattering perturbation parameter and the shift of the inhomogeneity from the middle plane, allowing one to reduce the uncertainties due to depth. This is important for optical mammography because effects of the depth can cause uncertainties in the derived tumor optical properties that are above 20% and the scattering properties of tumors differ from those of the sourrounding healthy tissue by a comparable extent.

© 2008 Optical Society of America

OCIS Codes
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.5280) Medical optics and biotechnology : Photon migration
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(290.1990) Scattering : Diffusion
(290.7050) Scattering : Turbid media

ToC Category:
Scattering

History
Original Manuscript: July 10, 2008
Revised Manuscript: September 6, 2008
Manuscript Accepted: September 12, 2008
Published: October 17, 2008

Virtual Issues
Vol. 3, Iss. 12 Virtual Journal for Biomedical Optics

Citation
Rosario Esposito, Sergio De Nicola, Marco Brambilla, Antonio Pifferi, Lorenzo Spinelli, and Maria Lepore, "Depth dependence of estimated optical properties of a scattering inclusion by time-resolved contrast functions," Opt. Express 16, 17667-17681 (2008)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-16-22-17667


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