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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 16, Iss. 22 — Oct. 27, 2008
  • pp: 18551–18556

Realtime Photoacoustic Microscopy of Murine Cardiovascular Dynamics

R.J. Zemp, L. Song, R. Bitton, K.K. Shung, and L.V. Wang  »View Author Affiliations


Optics Express, Vol. 16, Issue 22, pp. 18551-18556 (2008)
http://dx.doi.org/10.1364/OE.16.018551


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Abstract

Non-invasive visualization of cardiovascular dynamics in small animals is challenging due to their rapid heart-rates. We present a realtime photoacoustic imaging system consisting of a 30-MHz ultrasound array transducer, receive electronics, a high-repetition-rate laser, and a multicore-computer, and demonstrate its ability to image optically-absorbing structures of the beating hearts of young athymic nude mice at rates of ~50 frames per second with 100 µm×25 µm spatial resolution. To our knowledge this is the first report of realtime photoacoustic imaging of physiological dynamics.

© 2008 Optical Society of America

OCIS Codes
(110.5100) Imaging systems : Phased-array imaging systems
(110.5120) Imaging systems : Photoacoustic imaging
(110.7170) Imaging systems : Ultrasound
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.3890) Medical optics and biotechnology : Medical optics instrumentation

ToC Category:
Imaging Systems

History
Original Manuscript: June 10, 2008
Revised Manuscript: August 8, 2008
Manuscript Accepted: August 10, 2008
Published: October 24, 2008

Virtual Issues
Vol. 3, Iss. 12 Virtual Journal for Biomedical Optics

Citation
R. J. Zemp, L. Song, R. Bitton, K. K. Shung, and L. V. Wang, "Realtime Photoacoustic Microscopy of Murine Cardiovascular Dynamics," Opt. Express 16, 18551-18556 (2008)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-16-22-18551


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References

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