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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 16, Iss. 23 — Nov. 10, 2008
  • pp: 19049–19062

Biofunctionalized tilted Fiber Bragg Gratings for label-free immunosensing

Séverine Maguis, Guillaume Laffont, Pierre Ferdinand, Benjamin Carbonnier, Khémara Kham, Tahar Mekhalif, and Marie-Claude Millot  »View Author Affiliations


Optics Express, Vol. 16, Issue 23, pp. 19049-19062 (2008)
http://dx.doi.org/10.1364/OE.16.019049


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Abstract

We present a study aimed at developing a label-free optical fiber biosensor for detection and quantification of biomolecules in real-time. The biosensor based on a Tilted Fiber Bragg Grating (TFBG) transduces a binding event between the probe and target molecules into a change in the refractive index of the medium surrounding the fiber. This work describes the experimental results obtained with three methods for immobilizing biomolecular probes on a TFBG silica cladding surface. Bovine serum albumin (BSA) and anti-BSA are used to assess the performances of the TFBG based biosensor in each configuration.

© 2008 Optical Society of America

OCIS Codes
(060.2370) Fiber optics and optical communications : Fiber optics sensors
(280.1415) Remote sensing and sensors : Biological sensing and sensors
(060.3735) Fiber optics and optical communications : Fiber Bragg gratings
(280.4788) Remote sensing and sensors : Optical sensing and sensors

ToC Category:
Fiber Optics and Optical Communications

History
Original Manuscript: August 7, 2008
Revised Manuscript: September 4, 2008
Manuscript Accepted: September 4, 2008
Published: November 4, 2008

Virtual Issues
Vol. 4, Iss. 1 Virtual Journal for Biomedical Optics

Citation
Séverine Maguis, Guillaume Laffont, Pierre Ferdinand, Benjamin Carbonnier, Khémara Kham, Tahar Mekhalif, and Marie-Claude Millot, "Biofunctionalized tilted Fiber Bragg Gratings for label-free immunosensing," Opt. Express 16, 19049-19062 (2008)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-16-23-19049


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