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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 16, Iss. 24 — Nov. 24, 2008
  • pp: 19434–19446

Simultaneous dual-band ultra-high resolution full-field optical coherence tomography

Delphine Sacchet, Julien Moreau, Patrick Georges, and Arnaud Dubois  »View Author Affiliations

Optics Express, Vol. 16, Issue 24, pp. 19434-19446 (2008)

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Ultrahigh-resolution full-field optical coherence tomography (FF-OCT) is demonstrated in the 800 nm and 1200 nm wavelength regions simultaneously using a Silicon-based (Si) CCD camera and an Indium Gallium Arsenide (InGaAs) camera as area detectors and a halogen lamp as illumination source. The FF-OCT setup is optimized to support the two broad spectral bands in parallel, achieving a detection sensitivity of ~90 dB and a micrometer-scale resolution in the three directions. Images of ex vivo biological tissues are presented (rabbit trachea and Xenopus laevis tadpole) with an increase in penetration depth at 1200 nm. A color image representation is applied to fuse both images and enhance spectroscopic property visualization.

© 2008 Optical Society of America

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(180.3170) Microscopy : Interference microscopy

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: July 24, 2008
Revised Manuscript: October 2, 2008
Manuscript Accepted: October 12, 2008
Published: November 10, 2008

Virtual Issues
Vol. 4, Iss. 1 Virtual Journal for Biomedical Optics

Delphine Sacchet, Julien Moreau, Patrick Georges, and Arnaud Dubois, "Simultaneous dual-band ultra-high resolution full-field optical coherence tomography," Opt. Express 16, 19434-19446 (2008)

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  1. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinsin, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991). [CrossRef] [PubMed]
  2. A. F. Fercher, "Optical coherence tomography," J. Biomed. Opt. 1, 157-173 (1996). [CrossRef]
  3. E. A. Swanson, J. A. Izatt, M. R. Hee, D. Huang, C. P. Lin, J. S. Schumann, C. A. Puliafito and J. G. Fujimoto, "In-vivo retinal imaging by optical coherence tomography," Opt. Lett. 18, 1864-1866 (1993). [CrossRef] [PubMed]
  4. G. J. Tearney, B. E. Bouma, S. A. Boppart, B. Golubovic, E. A. Swanson, and G. J. Fujimoto, "Rapid acquisition of in-vivo biological images by use of optical coherence tomography," Opt. Lett. 21, 1408-1410 (1996). [CrossRef] [PubMed]
  5. J. G. Fujimoto, "Optical coherence tomography for ultrahigh resolution in-vivo imaging," Nat. Biotechnol. 21, 1361-1367 (2003). [CrossRef] [PubMed]
  6. L. Vabre, A. Dubois, and A. C. Boccara, "Thermal-light full-field optical coherence tomography," Opt. Lett. 27, 530-533 (2002). [CrossRef]
  7. A. Dubois, K. Grieve, G. Moneron, R. Lecaque, L. Vabre, and A. C. Boccara, "Ultrahigh-resolution fullfield optical coherence tomography," Appl. Opt. 43, 2874 (2004). [CrossRef] [PubMed]
  8. W. Y. Oh, B. E. Bouma, N. Iftimia, S. H. Yun, R. Yelin, and G. J. Tearney, "Ultrahigh-resolution full-field optical coherence microscopy using InGaAs camera," Opt. Express 14, 726-735 (2006). [CrossRef] [PubMed]
  9. A. Dubois, G. Moneron, and A. C. Boccara, "Thermal-light full-field optical coherence tomography in the 1.2 μm wavelength region," Opt. Commun. 266, 738-743 (2006). [CrossRef]
  10. A. Dubois, G. Moneron, K. Grieve, and A. C. Boccara, "Three-dimensional cellular-level imaging using full-field optical coherence tomography," Phys. Med. Biol. 49, p. 1227-1234 (2004). [CrossRef] [PubMed]
  11. B. Laude, A. De. Martino, B. Drévillon, L. Benattar, and L. Schwartz, "Full-field optical coherence tomography with thermal light," Appl. Opt. 41, 2059-2064 (2002). [CrossRef]
  12. J. Na, W. J. Choi, E. S. Choi, S. Y. Ryu, and B. H. Lee, "Image restoration method based on Hilbert transform for full-field optical coherence tomography," Appl. Opt. 47, 459-466 (2008). [CrossRef] [PubMed]
  13. U. Morgner, W. Drexler, F. X. Kärtner, X. D. Li, C. Pitris, E. P. Ippen, and G. J. Fujimoto, "Spectroscopic optical coherence tomography," Opt. Lett. 25, 111-113 (2000). [CrossRef]
  14. D. C. Adler, T. H. Ko, P. R. Herz, and J. G. Fujimoto, "Optical coherence tomography contrast enhancement using spectroscopic analysis with spectral autocorrelation," Opt. Express 12, 5489-5501 (2004). [CrossRef]
  15. D. J. Faber, E. G. Mik, M. C. G. Aalders, and T. G. van Leeuwen, "Toward assessments of blood oxygen saturation by spectroscopic optical coherence tomography," Opt. Lett. 30, 1015-1017 (2005). [CrossRef] [PubMed]
  16. A. Dubois, J. Moreau, and A. C. Boccara, "Spectroscopic ultrahigh-resolution full-field optical coherence microscopy," Opt. Express 16, 17082-17091 (2008). [CrossRef] [PubMed]
  17. Q1. V. M. Gelikonov, G. V. Gelikonov, and F. I. Feldchtein, "Two-wavelength optical coherence tomography," Radiophys. Quantum Electron. 47, 848-859 (2004). [CrossRef]
  18. Y. Pan and D. L. Farkas, "Noninvasive imaging of living human skin with dual-wavelength optical coherence tomography in two and three dimensions," J. Biomed. Opt. 3, 446-455 (1998). [CrossRef]
  19. F. Spöler, S. Kray, P. Grychtol, B. Hermes, J. Bornemann, M. Först, and H. Kurz, "Simultaneous dual-band ultra-high resolution optical coherence tomography," Opt. Express 15, 10832-10842 (2007). [CrossRef] [PubMed]
  20. A. D. Aguirre, N. Nishizawa, W. Seitz, M. Ledere, D. Kopf, and J. G. Fujimoto, "Continuum generation in a novel photonic crystal fiber for ultrahigh resolution optical coherence tomography at 800 nm and 1300 nm," Opt. Express 14, 1145-1160 (2006). [CrossRef] [PubMed]
  21. D. M. Gale, M. I. Pether, and J. C. Dainty, "Linnik microscope imaging of integrated circuit structures," Appl. Opt 35, 131-148 (1996). [CrossRef] [PubMed]
  22. A. Dubois, L. Vabre, A. C. Boccara, and E. Beaurepaire, "High-resolution full-field optical coherence tomography with a Linnik microscope," Appl. Opt. 41, 805-812 (2002). [CrossRef] [PubMed]
  23. G. M. Hale and M. R. Querry, "Optical constants of water in the 200 nm - 200 μm wavelength region," Appl. Opt 12, 555-563 (1973). [CrossRef] [PubMed]
  24. Q2. Y. Coello, B. Xu, T. L. Miller, V. V. Lozovoy, and M. Dantus, "Group-velocity dispersion measurements of water, seawater and ocular components using multiphoton intrapulse interference scan phase," Appl. Opt. 46, 3894-8401 (2007). [CrossRef]
  25. P. Parsa, S. L. Jacques, and N. S. Nishioka, "Optical properties of rat liver between 350 and 2200 nm," Appl. Opt. 28, 2325-2330 (1989). [CrossRef] [PubMed]
  26. J. M. Schmitt, A. Knuttel, M. Yadlowsky, and M. A. Eckhaus, "Optical coherence tomography of a dense tissue: statistics of attenuation and backscattering," Phys. Med. Biol. 39, 1705-1720 (1994). [CrossRef] [PubMed]
  27. S. T. Flock, S. L. Jacques, B. C. Wilson, W. M. Star, and M. J. C. van Gemert, "Optical properties of Intralipid: a phantom medium for light propagation studies," Lasers Surg. Med. 12, 510-519 (1992). [CrossRef] [PubMed]
  28. H. G. van Staveren, C. J. M. Moes, J. van Marle, S. A. Prahl, and M. J. C. van Gemert, "Light scattering in Intralipid-10% in the wavelength range of 400-1100 nanometers," Appl. Opt. 30, 4507-4515 (1991). [CrossRef] [PubMed]

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