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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 16, Iss. 3 — Feb. 4, 2008
  • pp: 1481–1486

Quantitative bioluminescence tomography guided by diffuse optical tomography

Qizhi Zhang, Lu Yin, Yiyong Tan, Zhen Yuan, and Huabei Jiang  »View Author Affiliations


Optics Express, Vol. 16, Issue 3, pp. 1481-1486 (2008)
http://dx.doi.org/10.1364/OE.16.001481


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Abstract

We present for the first time experimental evidence that the quantitative accuracy of bioluminescence tomography (BLT) can be significantly improved by incorporating prior spatial distribution of optical properties of heterogeneous media obtained from diffuse optical tomography (DOT). A series of experiments were conducted using a CCD-based scanning system where millimeter-size bioluminescent targets were embedded in a 3×3×5cm optically heterogeneous scattering medium. The results show that the BLT images with the recovered optical property distribution in place are considerably better reconstructed compared to that without such prior information, in terms of the location, size and source strength of the targets.

© 2008 Optical Society of America

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.6960) Medical optics and biotechnology : Tomography

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: November 16, 2007
Revised Manuscript: January 17, 2008
Manuscript Accepted: January 17, 2008
Published: January 22, 2008

Virtual Issues
Vol. 3, Iss. 3 Virtual Journal for Biomedical Optics

Citation
Qizhi Zhang, Lu Yin, Yiyong Tan, Zhen Yuan, and Huabei Jiang, "Quantitative bioluminescence tomography guided by diffuse optical tomography," Opt. Express 16, 1481-1486 (2008)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-16-3-1481


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References

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