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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 16, Iss. 3 — Feb. 4, 2008
  • pp: 1748–1757

Volumetric sub-surface imaging using spectrally encoded endoscopy

D. Yelin, B. E. Bouma, and G. J. Tearney  »View Author Affiliations

Optics Express, Vol. 16, Issue 3, pp. 1748-1757 (2008)

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Endoscopic imaging below tissue surfaces and through turbid media may provide improved diagnostic capabilities and visibility in surgical settings. Spectrally encoded endoscopy (SEE) is a recently developed method that utilizes a single optical fiber, miniature optics and a diffractive grating for high-speed imaging through small diameter, flexible endoscopic probes. SEE has also been shown to provide three-dimensional topological imaging capabilities. In this paper, we have configured SEE to additionally image beneath tissue surfaces, by increasing the system’s sensitivity and acquiring the complex spectral density for each spectrally resolved point on the sample. In order to demonstrate the capability of SEE to obtain subsurface information, we have utilized the system to image a resolution target through intralipid solution, and conduct volumetric imaging of a mouse embryo and excised human middle-ear ossicles. Our results demonstrate that real-time subsurface imaging is possible with this miniature endoscopy technique.

© 2008 Optical Society of America

OCIS Codes
(110.1650) Imaging systems : Coherence imaging
(170.2150) Medical optics and biotechnology : Endoscopic imaging
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.6900) Medical optics and biotechnology : Three-dimensional microscopy

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: October 10, 2007
Revised Manuscript: November 21, 2007
Manuscript Accepted: December 14, 2007
Published: January 25, 2008

Virtual Issues
Vol. 3, Iss. 3 Virtual Journal for Biomedical Optics

D. Yelin, B. E. Bouma, and G. J. Tearney, "Volumetric sub-surface imaging using spectrally encoded endoscopy," Opt. Express 16, 1748-1757 (2008)

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