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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 16, Iss. 4 — Feb. 18, 2008
  • pp: 2387–2397

Cavity-enhanced optical frequency comb spectroscopy: application to human breath analysis

Michael J. Thorpe, David Balslev-Clausen, Matthew S. Kirchner, and Jun Ye  »View Author Affiliations


Optics Express, Vol. 16, Issue 4, pp. 2387-2397 (2008)
http://dx.doi.org/10.1364/OE.16.002387


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Abstract

Broad-bandwidth, high-spectral-resolution optical detection of human breath has identified multiple important biomarkers correlated with specific diseases and metabolic processes. This optical-frequency-comb-based breath analysis system comes with excellent performance in all criteria: high detection sensitivity, ability to identify and distinguish a large number of analytes, and simultaneous, real-time information processing. We demonstrate a minimum detectable absorption of 8×10-10 cm-1, a spectral resolution of 800 MHz, and 200 nm of spectral coverage from 1.5 to 1.7 µm where strong and unique molecular fingerprints exist for many biomarkers. We present a series of breath measurements including stable isotope ratios of CO2, breath concentrations of CO, and the presence of trace concentrations of NH3 in high concentrations of H2O.

© 2008 Optical Society of America

OCIS Codes
(120.3890) Instrumentation, measurement, and metrology : Medical optics instrumentation
(140.4050) Lasers and laser optics : Mode-locked lasers
(300.1030) Spectroscopy : Absorption

ToC Category:
Spectroscopy

History
Original Manuscript: December 17, 2007
Revised Manuscript: January 18, 2008
Manuscript Accepted: January 23, 2008
Published: February 5, 2008

Virtual Issues
Vol. 3, Iss. 3 Virtual Journal for Biomedical Optics

Citation
Michael J. Thorpe, David Balslev-Clausen, Matthew S. Kirchner, and Jun Ye, "Cavity-enhanced optical frequency comb spectroscopy: application to human breath analysis," Opt. Express 16, 2387-2397 (2008)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-16-4-2387


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