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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 16, Iss. 4 — Feb. 18, 2008
  • pp: 2469–2485

Effects of axial resolution improvement on optical coherence tomography (OCT) imaging of gastrointestinal tissues

Yu Chen, Aaron D. Aguirre, Pei-Lin Hsiung, Shu-Wei Huang, Hiroshi Mashimo, Joseph M. Schmitt, and James G. Fujimoto  »View Author Affiliations

Optics Express, Vol. 16, Issue 4, pp. 2469-2485 (2008)

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Optical coherence tomography (OCT) is an emerging medical imaging technology which generates high resolution, cross-sectional images in situ, without the need for excisional biopsy. Previous clinical studies using endoscopic OCT with standard 10–15 µm axial resolution have demonstrated its capability in diagnosing Barrett’s esophagus (BE) and high-grade dysplasia (HGD). Quantitative OCT image analysis has shown promise for detecting HGD in Barrett’s esophagus patients. We recently developed an endoscopic OCT system with an improved axial resolution of ~5 µm. The goal in this manuscript is to compare standard resolution OCT and ultrahigh resolution OCT (UHR-OCT) for image quality and computeraided detection using normal and Barrett’s esophagus. OCT images of gastrointestinal (GI) tissues were obtained using UHR-OCT (5.5 µm) and standard resolution OCT (13 µm). Image quality including the speckle size and sharpness was compared. Texture features of endoscopic OCT images from normal and Barrett’s esophagus were extracted using quantitative metrics including spatial frequency analysis and statistical texture analysis. These features were analyzed using principal component analysis (PCA) to reduce the vector dimension and increase the discriminative power, followed by linear discrimination analysis (LDA). UHR-OCT images of GI tissues improved visualization of fine architectural features compared to standard resolution OCT. In addition, the quantitative image feature analysis showed enhanced discrimination of normal and Barrett’s esophagus with UHR-OCT. The ability of UHR-OCT to resolve tissue morphology at improved resolution enables visualization of subtle features in OCT images, which may be useful in disease diagnosis. Enhanced classification of image features using UHR-OCT promises to help in the computer-aided diagnosis of GI diseases.

© 2008 Optical Society of America

OCIS Codes
(110.2960) Imaging systems : Image analysis
(110.4500) Imaging systems : Optical coherence tomography
(170.2150) Medical optics and biotechnology : Endoscopic imaging
(170.3880) Medical optics and biotechnology : Medical and biological imaging

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: October 12, 2007
Revised Manuscript: January 11, 2008
Manuscript Accepted: February 1, 2008
Published: February 6, 2008

Virtual Issues
Vol. 3, Iss. 3 Virtual Journal for Biomedical Optics

Yu Chen, Aaron D. Aguirre, Pei-Lin Hsiung, Shu-Wei Huang, Hiroshi Mashimo, Joseph M. Schmitt, and James G. Fujimoto, "Effects of axial resolution improvement on optical coherence tomography (OCT) imaging of gastrointestinal tissues," Opt. Express 16, 2469-2485 (2008)

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