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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 16, Iss. 4 — Feb. 18, 2008
  • pp: 2709–2719

Optical diagnosis of cervical intraepithelial neoplasm (CIN) using polarization-sensitive optical coherence tomography

Sang-Won Lee, Ji-Yeong Yoo, Jin-Ho Kang, Moon-Sik Kang, Soon-Hee Jung, Yosep Chong, Dong-Su Cha, Kyung-Hee Han, and Beop-Min Kim  »View Author Affiliations


Optics Express, Vol. 16, Issue 4, pp. 2709-2719 (2008)
http://dx.doi.org/10.1364/OE.16.002709


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Abstract

We present a polarization-sensitive optical coherence tomography (PS-OCT) technique that can quantify the polarization changes (the degrees of circular polarization, DOCP) caused by the scattering changes induced by cervical intraepithelial neoplasia (CIN). The axial and lateral resolutions of our PS-OCT system are 13 µm and 15 µm, respectively. Uterine cervical conization tissue samples from 18 patients were examined, and 71 areas were imaged for in vitro studies; about 2–4 areas per sample were imaged and processed for diagnosis. The scanned areas had a size of 2 mm (axial) × 2 mm (lateral) × 4 mm (transversal). We quantified the slope of the axial decay of the DOCP signal near the cervical epithelium by a linear fitting procedure. The excised samples were then investigated by two pathologists, and their histological findings were later compared with the PS-OCT results. Our results show that the sensitivity and specificity are 94.7% and 71.2%, respectively.

© 2008 Optical Society of America

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(120.5820) Instrumentation, measurement, and metrology : Scattering measurements
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(290.5855) Scattering : Scattering, polarization

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: December 10, 2007
Revised Manuscript: January 18, 2008
Manuscript Accepted: January 28, 2008
Published: February 12, 2008

Virtual Issues
Vol. 3, Iss. 3 Virtual Journal for Biomedical Optics

Citation
Sang-Won Lee, Ji-Yeong Yoo, Jin-Ho Kang, Moon-Sik Kang, Soon-Hee Jung, Yosep Chong, Dong-Su Cha, Kyung-Hee Han, and Beop-Min Kim, "Optical diagnosis of cervical intraepithelial neoplasm (CIN) using polarization-sensitive optical coherence tomography," Opt. Express 16, 2709-2719 (2008)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-16-4-2709


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