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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 16, Iss. 6 — Mar. 17, 2008
  • pp: 3776–3785

Ultrasound imaging to monitor photothermal therapy – Feasibility study

Jignesh Shah, Salavat R. Aglyamov, Konstantin Sokolov, Thomas E. Milner, and Stanislav Y. Emelianov  »View Author Affiliations

Optics Express, Vol. 16, Issue 6, pp. 3776-3785 (2008)

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This study investigates the feasibility of ultrasound imaging to monitor temperature changes during photothermal treatment. Experiments were performed on tissue-mimicking phantoms and ex-vivo animal tissue samples. Gold nanoparticles were utilized as photoabsorbers. Prior to laser irradiation, structural features of the phantoms and tissue were visualized by ultrasound imaging. Ultrasound thermal imaging, performed during laser heating, showed that the temperature elevation was localized to the region of embedded or injected nanoparticles. The results of our study suggest that ultrasound imaging is a candidate approach to remotely guide photothermal therapy.

© 2008 Optical Society of America

OCIS Codes
(140.3330) Lasers and laser optics : Laser damage
(170.1020) Medical optics and biotechnology : Ablation of tissue
(170.7170) Medical optics and biotechnology : Ultrasound
(350.5340) Other areas of optics : Photothermal effects
(280.6780) Remote sensing and sensors : Temperature

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: November 14, 2007
Revised Manuscript: February 21, 2008
Manuscript Accepted: March 2, 2008
Published: March 7, 2008

Virtual Issues
Vol. 3, Iss. 4 Virtual Journal for Biomedical Optics

Jignesh Shah, Salavat R. Aglyamov, Konstantin Sokolov, Thomas E. Milner, and Stanislav Y. Emelianov, "Ultrasound imaging to monitor photothermal therapy – Feasibility study," Opt. Express 16, 3776-3785 (2008)

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