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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 16, Iss. 9 — Apr. 28, 2008
  • pp: 6170–6182

Measurement of oxygen saturation in the retina with a spectroscopic sensitive multi aperture camera

Jessica C. Ramella-Roman, Scott A. Mathews, Haryipria Kandimalla, Afshin Nabili, Donald D. Duncan, Salvatore A. D’Anna, Syed Mahmood Shah, and Quan Dong Nguyen  »View Author Affiliations


Optics Express, Vol. 16, Issue 9, pp. 6170-6182 (2008)
http://dx.doi.org/10.1364/OE.16.006170


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Abstract

We introduce a new multi aperture system capable of capturing six identical images of the human fundus at six different spectral bands. The system is based on a lenslet array architecture and is well suited for spectroscopy application. The multi-aperture system was interfaced with a fundus camera to acquire spectroscopic sensitive images of the retina vessel and ultimately to calculate oxygen saturation in the retina in vivo. In vitro testing showed that the system is able to accurately reconstruct curves of partially oxygenated hemoglobin. In vivo testing on healthy volunteers was conducted and yielded results of oxygen saturation similar to the one reported in the literature, with arterial SO2~0.95 and venous SO2~0.5.

© 2008 Optical Society of America

OCIS Codes
(120.3890) Instrumentation, measurement, and metrology : Medical optics instrumentation
(170.4730) Medical optics and biotechnology : Optical pathology

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: June 29, 2007
Revised Manuscript: January 11, 2008
Manuscript Accepted: February 4, 2008
Published: April 17, 2008

Virtual Issues
Vol. 3, Iss. 5 Virtual Journal for Biomedical Optics

Citation
Jessica C. Ramella-Roman, Scott A. Mathews, Haripriya Kandimalla, Afshin Nabili, Donald D. Duncan, Salvatore A. D'Anna, Syed M. Shah, and Quan D. Nguyen, "Measurement of oxygen saturation in the retina with a spectroscopic sensitive multi aperture camera," Opt. Express 16, 6170-6182 (2008)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-16-9-6170


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