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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 17, Iss. 1 — Jan. 5, 2009
  • pp: 80–86

Nanofabricated upconversion nanoparticles for photodynamic therapy

Baris Ungun, Robert K. Prud’homme, Stephanie J. Budijono, Jingning Shan, Shuang Fang Lim, Yiguang Ju, and Robert Austin  »View Author Affiliations

Optics Express, Vol. 17, Issue 1, pp. 80-86 (2009)

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We present a novel process for the production of three-layer Composite Nanoparticles (CNPs) in the size range 100–300 nm with an up-converting phosphor interior, a coating of porphyrin photosensitizer, and a biocompatible PEG outer layer to prevent clearance by the reticuloendothelial system. We show that these CNPs produce millimolar amounts of singlet oxygen at NIR intensities far less than other two-photon techniques.

© 2009 Optical Society of America

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: October 27, 2008
Revised Manuscript: December 8, 2008
Manuscript Accepted: December 10, 2008
Published: December 22, 2008

Virtual Issues
Vol. 4, Iss. 3 Virtual Journal for Biomedical Optics

Baris Ungun, Robert K. Prud'homme, Stephanie J. Budijon, Jingning Shan, Shuang F. Lim, Yiguang Ju, and Robert Austin, "Nanofabricated upconversion nanoparticles for photodynamic therapy," Opt. Express 17, 80-86 (2009)

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  1. S. Heer, K. Kompe, H. U. Gudel, and M. Haase, "Highly efficient multicolour upconversion emission in transparent colloids of lanthanide-doped NaYF4 nanocrystals," Adv. Mat. 16, 2102-+ (2004). [CrossRef]
  2. K. Kuningas, T. Rantanen, U. Karhunen, T. Lovgren, and T. Soukka, "Simultaneous use of time-resolved fluorescence and anti-stokes photoluminescence in a bioaffinity assay," Anal. Chem. 77, 2826-2834 (2005). [CrossRef] [PubMed]
  3. K. van de Rijke, H. Zijlmans, S. V. Li, T. A. K. Raap, R. S. Niedbala, and H. J. Tanke, "Up-converting phosphor reporters for nucleic acid microarrays," Nature Biotech. 19, 273-276 (2001). [CrossRef]
  4. M. Zuiderwijk, H. J. Tanke, R. S. Niedbala, and P. Corstjens, "An amplification-free hybridization-based DNA assay to detect Streptococcus pneumoniae utilizing the up-conversion phosphor technology," Clin. Biochem. 36, 401-403 (2003). [CrossRef] [PubMed]
  5. S. F. Lim, R. Riehn, W. S. Ryu, N. Khanarian, C. K. Tung, D. Tank, and R. H. Austin, "In vivo and scanning electron microscopy imaging of upconverting nanophosphors in Caenorhabditis elegans," Nano Lett.6-2 (2006).
  6. V. P. Torchilin, and V. S. Trubetskoy, "Which Polymers Can Make Nanoparticulate Drug Carriers Long-Circulating," Adv. Drug Del. Rev. 16, 141-155 (1995). [CrossRef]
  7. J. Shan and Y. G. Ju, "Synthesis, characterization and SiO2 coating of NaF4Y:Er3+ upconversion nanophosphors using high temperature ligands," Adv. Mat.Submitted (2007).
  8. B. K. Johnson and R. K. Prud'homme, "Flash NanoPrecipitation of organic actives and block copolymers using a confined impinging jets mixer," Australian J. Chem. 56, 1021-1024 (2003). [CrossRef]
  9. F. Auzel, "Upconversion and anti-stokes processes with f and d ions in solids," Chem. Rev. 104, 139-173 (2004). [CrossRef] [PubMed]
  10. M. J. Moreno, E. Monson, R. G. Reddy, A. Rehemtulla, B. D. Ross, M. Philbert, R. J. Schneider, and R. Kopelman, "Production of singlet oxygen by Ru(dpp(SO3)(2))(3) incorporated in polyacrylamide PEBBLES," Sens. Actuat. B-Chem. 90, 82-89 (2003). [CrossRef]
  11. B. A. Lindig, M. A. J. Rodgers, and A. P. Schaap, "Determination of the Lifetime of Singlet Oxygen in D2o Using 9,10-Anthracenedipropionic Acid, a Water-Soluble Probe," J. Am. Chem. Soc. 102, 5590-5593 (1980). [CrossRef]
  12. D. K. Chatterjee and Z. Yong, "Upconverting nanoparticles as nanotransducers for photodynamic therapy in cancer cells," Nanomed. 3, 73-82 (2008). [CrossRef]
  13. S. M. Ansell, S. A. Johnstone, P. G. Tardi, L. Lo, S. W. Xie, Y. Shu, T. O. Harasym, N. L. Harasym, L. Williams, D. Bermudes, B. D. Liboiron, W. Saad, R. K. Prud'homme, and L. D. Mayer, "Modulating the therapeutic activity of nanoparticle delivered paclitaxel by manipulating the hydrophobicity of prodrug conjugates," J. Med. Chem. 51, 3288-3296 (2008). [CrossRef] [PubMed]
  14. P. Zhang, W. Steelant, M. Kumar, and M. Scholfield, "Versatile photosensitizers for photodynamic therapy at infrared excitation," J. Am. Chem. Soc. 129, 4526 (2007). [CrossRef] [PubMed]
  15. H. Maeda, J. Fang, T. Inutsuka, and Y. Kitamoto, "Vascular permeability enhancement in solid tumor: various factors, mechanisms involved and its implications," Int. Immunopharm. 3, 319-328 (2003). [CrossRef]
  16. M. E. Gindy, S. Ji, T. R. Hoye, A. Z. Panagiotopoulos, and R. K. Prud’homme, "Preparation of Poly(ethylene glycol) Protected Nanoparticles with Variable Bioconjugate Ligand Density," Biomacromol. 9, 2705-2711 (2008). [CrossRef]
  17. M. E. Gindy, A. Z. Panagiotopoulos, and R. K. Prud'homme, "Composite block copolymer stabilized nanoparticles: Simultaneous encapsulation of organic actives and inorganic nanostructures," Langmuir 24, 83-90 (2008). [CrossRef]
  18. Y. Liu, K. Kathan, W. Saad, and R. K. Prud'homme, "Ostwald ripening of beta-carotene nanoparticles," Phys. Rev. Lett. 98 (2007). [PubMed]

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