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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 17, Iss. 1 — Jan. 5, 2009
  • pp: 80–86

Nanofabricated upconversion nanoparticles for photodynamic therapy

Baris Ungun, Robert K. Prud’homme, Stephanie J. Budijono, Jingning Shan, Shuang Fang Lim, Yiguang Ju, and Robert Austin  »View Author Affiliations


Optics Express, Vol. 17, Issue 1, pp. 80-86 (2009)
http://dx.doi.org/10.1364/OE.17.000080


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Abstract

We present a novel process for the production of three-layer Composite Nanoparticles (CNPs) in the size range 100–300 nm with an up-converting phosphor interior, a coating of porphyrin photosensitizer, and a biocompatible PEG outer layer to prevent clearance by the reticuloendothelial system. We show that these CNPs produce millimolar amounts of singlet oxygen at NIR intensities far less than other two-photon techniques.

© 2009 Optical Society of America

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: October 27, 2008
Revised Manuscript: December 8, 2008
Manuscript Accepted: December 10, 2008
Published: December 22, 2008

Virtual Issues
Vol. 4, Iss. 3 Virtual Journal for Biomedical Optics

Citation
Baris Ungun, Robert K. Prud'homme, Stephanie J. Budijon, Jingning Shan, Shuang F. Lim, Yiguang Ju, and Robert Austin, "Nanofabricated upconversion nanoparticles for photodynamic therapy," Opt. Express 17, 80-86 (2009)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-17-1-80


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References

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