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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 17, Iss. 11 — May. 25, 2009
  • pp: 8892–8906

In vitro ovarian tumor growth and treatment response dynamics visualized with time-lapse OCT imaging

Conor L. Evans, Imran Rizvi, Tayyaba Hasan, and Johannes F. de Boer  »View Author Affiliations


Optics Express, Vol. 17, Issue 11, pp. 8892-8906 (2009)
http://dx.doi.org/10.1364/OE.17.008892


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Abstract

In vitro three-dimensional models for metastatic ovarian cancer have been useful for recapitulating the human disease. These spheroidal tumor cultures, however, can grow in excess of 1 mm in diameter, which are difficult to visualize without suitable imaging technology. Optical coherence tomography (OCT) is an ideal live imaging method for non-perturbatively visualizing these complex systems. OCT enabled detailed observations of the model at both nodular and cellular levels, revealing growth dynamics not previously observed. The development of a time-lapse OCT system, capable of automated, multidimensional acquisition, further provided insights into the growth and chemotherapeutic response of ovarian cancer.

© 2009 Optical Society of America

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4440) Medical optics and biotechnology : ObGyn
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(180.6900) Microscopy : Three-dimensional microscopy

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: March 2, 2009
Revised Manuscript: April 23, 2009
Manuscript Accepted: April 27, 2009
Published: May 12, 2009

Virtual Issues
Vol. 4, Iss. 7 Virtual Journal for Biomedical Optics

Citation
Conor L. Evans, Imran Rizvi, Tayyaba Hasan, and Johannes F. de Boer, "In vitro ovarian tumor growth and treatment response dynamics visualized with time-lapse OCT imaging," Opt. Express 17, 8892-8906 (2009)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-17-11-8892


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