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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 17, Iss. 15 — Jul. 20, 2009
  • pp: 12571–12581

Cerebral hemodynamics in preterm infants during positional intervention measured with diffuse correlation spectroscopy and transcranial Doppler ultrasound

Erin M. Buckley, Noah M. Cook, Turgut Durduran, Meeri N. Kim, Chao Zhou, Regine Choe, Guoqiang Yu, Susan Shultz, Chandra M. Sehgal, Daniel J. Licht, Peter H. Arger, Mary E. Putt, Hallam Hurt, and Arjun G. Yodh  »View Author Affiliations

Optics Express, Vol. 17, Issue 15, pp. 12571-12581 (2009)

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Four very low birth weight, very premature infants were monitored during a 12° postural elevation using diffuse correlation spectroscopy (DCS) to measure microvascular cerebral blood flow (CBF) and transcranial Doppler ultrasound (TCD) to measure macrovascular blood flow velocity in the middle cerebral artery. DCS data correlated significantly with peak systolic, end diastolic, and mean velocities measured by TCD (pA=0.036, 0.036, 0.047). Moreover, population averaged TCD and DCS data yielded no significant hemodynamic response to this postural change (p>0.05). We thus demonstrate feasibility of DCS in this population, we show correlation between absolute measures of blood flow from DCS and blood flow velocity from TCD, and we do not detect significant changes in CBF associated with a small postural change (12°) in these patients.

© 2009 Optical Society of America

OCIS Codes
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.6480) Medical optics and biotechnology : Spectroscopy, speckle
(170.7170) Medical optics and biotechnology : Ultrasound
(290.4210) Scattering : Multiple scattering

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: April 23, 2009
Revised Manuscript: June 3, 2009
Manuscript Accepted: June 4, 2009
Published: July 9, 2009

Virtual Issues
Vol. 4, Iss. 9 Virtual Journal for Biomedical Optics

Erin M. Buckley, Noah M. Cook, Turgut Durduran, Meeri N. Kim, Chao Zhou, Regine Choe, Guoqiang Yu, Susan Schultz, Chandra M. Sehgal, Daniel J. Licht, Peter H. Arger, Mary E. Putt, Hallam H. Hurt, and Arjun G. Yodh, "Cerebral hemodynamics in preterm infants during positional intervention measured with diffuse correlation spectroscopy and transcranial Doppler ultrasound," Opt. Express 17, 12571-12581 (2009)

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