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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 17, Iss. 15 — Jul. 20, 2009
  • pp: 12571–12581

Cerebral hemodynamics in preterm infants during positional intervention measured with diffuse correlation spectroscopy and transcranial Doppler ultrasound

Erin M. Buckley, Noah M. Cook, Turgut Durduran, Meeri N. Kim, Chao Zhou, Regine Choe, Guoqiang Yu, Susan Shultz, Chandra M. Sehgal, Daniel J. Licht, Peter H. Arger, Mary E. Putt, Hallam Hurt, and Arjun G. Yodh  »View Author Affiliations


Optics Express, Vol. 17, Issue 15, pp. 12571-12581 (2009)
http://dx.doi.org/10.1364/OE.17.012571


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Abstract

Four very low birth weight, very premature infants were monitored during a 12° postural elevation using diffuse correlation spectroscopy (DCS) to measure microvascular cerebral blood flow (CBF) and transcranial Doppler ultrasound (TCD) to measure macrovascular blood flow velocity in the middle cerebral artery. DCS data correlated significantly with peak systolic, end diastolic, and mean velocities measured by TCD (pA=0.036, 0.036, 0.047). Moreover, population averaged TCD and DCS data yielded no significant hemodynamic response to this postural change (p>0.05). We thus demonstrate feasibility of DCS in this population, we show correlation between absolute measures of blood flow from DCS and blood flow velocity from TCD, and we do not detect significant changes in CBF associated with a small postural change (12°) in these patients.

© 2009 Optical Society of America

OCIS Codes
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.6480) Medical optics and biotechnology : Spectroscopy, speckle
(170.7170) Medical optics and biotechnology : Ultrasound
(290.4210) Scattering : Multiple scattering

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: April 23, 2009
Revised Manuscript: June 3, 2009
Manuscript Accepted: June 4, 2009
Published: July 9, 2009

Virtual Issues
Vol. 4, Iss. 9 Virtual Journal for Biomedical Optics

Citation
Erin M. Buckley, Noah M. Cook, Turgut Durduran, Meeri N. Kim, Chao Zhou, Regine Choe, Guoqiang Yu, Susan Schultz, Chandra M. Sehgal, Daniel J. Licht, Peter H. Arger, Mary E. Putt, Hallam H. Hurt, and Arjun G. Yodh, "Cerebral hemodynamics in preterm infants during positional intervention measured with diffuse correlation spectroscopy and transcranial Doppler ultrasound," Opt. Express 17, 12571-12581 (2009)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-17-15-12571


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References

  1. J. A. Martin, B. E. Hamilton, P. D. Sutton, S. J. Ventura, F. Menacker, S. Kirmeyer, and M. L. Munson, "Births: Final Data for 2005," Tech. Rep. 6, National Center for Health Statistics (2007).
  2. M. C. Allen, "Neurodevelopmental outcomes of preterm infants," Curr. Opin. Neurol. 21(2), 123-128 (2008). [CrossRef]
  3. J. M. Perlman, "White matter injury in the preterm infant: an important determination of abnormal neurodevelopment outcome," Early Hum. Dev. 53, 99-120 (1998). [CrossRef]
  4. A. J. du Plessis and J. J. Volpe, "Perinatal brain injury in the preterm and term newborn," Curr. Opin. Neurol. 15, 151-7 (2002). [CrossRef] [PubMed]
  5. S. A. Back, B. H. Han, N. L. Luo, C. A. Chricton, S. Xanthoudakis, J. Tam, K. L. Arvin, and D. M. Holtzman," Selective Vulnerability of Late Oligodendrocyte Progenitors to Hypoxia-Ischemia," J. Neurosci. 22(2), 455-463 (2002).
  6. G. Greisen, "Brain Monitoring in the Neonate-the Rationale," Clin. Perinatol. 33(3), 613-618 (2006).
  7. D. H. Evans and W. N. McDicken, Doppler Ultrasound: Physics, Instrumentation, and Signal Processing, 2nd ed. (John Wiley and Sons, Ltd, New York, NY, 2000).
  8. C. Romagnoli, C. Giannantonio, M. De Carolis, F. Gallini, E. Zecca, and P. Papacci, "Neonatal color Doppler US study: Normal values of cerebral blood flow velocities in preterm infants in the first month of life," Ultrasound Med. Biol. 32, 321-331 (2006). [CrossRef] [PubMed]
  9. N. Evans, M. Kluckow, M. Simmons, and D. Osborn, "Which to measure, systemic or organ blood flow? Middle cerebral artery and superior vena cava flow in very preterm infants," Arch. Dis. Child Fetal Neonatal Ed. 87(3), F181-184 (2002). [CrossRef]
  10. H. A. Kontos, "Validity of cerebral arterial blood flow calculations from velocity measurements," Stroke 20(1), 1-3 (1989). [CrossRef]
  11. M. Drayton and R. Skidmore, "Vasoactivity of the major intracranial arteries in newborn infants," Arch. Dis. Child 62(3), 236-240 (1987). [CrossRef]
  12. M. Y. Anthony, D. H. Evans, and M. I. Levene, "Neonatal cerebral blood flow velocity responses to changes in posture," Arch. Dis. Child 69(3 Spec No), 304-308 (1993). [CrossRef]
  13. A. Yodh and B. Chance, "Spectroscopy and Imaging with Diffusing Light," Phys. Today48, 34-40 (1995).
  14. A. J. Wolfberg and A. J. du Plessis, "Near-infrared spectroscopy in the fetus and neonate," Clin. Perinatol. 33(3), 707-728 (2006). [CrossRef]
  15. A. D. Edwards, C. Richardson, M. Cope, J. S. Wyatt, D. T. Delpy, and E. O. R. Reynolds, "Cotside measurement of cerebral blood-flow in ill newborn infants by near-infrared spectroscopy," The Lancet 2(8614), 770-771 (1988). [CrossRef]
  16. G. Maret and P. E. Wolf, "Multiple light scattering from disordered media. The effect of Brownian motion of scatterers," Z. Naturforsch. B 65(4), 409-413 (1987).
  17. D. J. Pine, D. A. Weitz, P. M. Chaikin, and E. Herbolzheimer, "Diffusing wave spectroscopy," Phys. Rev. Lett. 60(12), 1134-1137 (1988). [CrossRef]
  18. D. A. Boas, L. E. Campbell, and A. G. Yodh, "Scattering and imaging with diffusing temporal field correlations," Phys. Rev. Lett. 75(9), 1855-1858 (1995). [CrossRef]
  19. D. A. Boas and A. G. Yodh, "Spatially varying dynamical properties of turbid media probed with diffusing temporal light correlation," J. Opt. Soc. Am. A 14(1), 192-215 (1997). [CrossRef]
  20. M. Heckmeier, S. E. Skipetrov, G. Maret, and R. Maynard, "Imaging of dynamic heterogeneities in multiplescattering media," J. Opt. Soc. Am. A 14(1), 185-191 (1997). [CrossRef]
  21. T. Durduran, "Non-invasive measurements of tissue hemodynamics with hybrid diffuse optical methods." Ph. D. Thesis, University of Pennsylvania (2004).
  22. C. Cheung, J. P. Culver, K. Takahashi, J. H. Greenberg, and A. G. Yodh, "In vivo cerebrovascular measurement combining diffuse near-infrared absorption and correlation spectroscopies," Phys. Med. Biol. 46, 2053-2065 (2001). [CrossRef] [PubMed]
  23. J. P. Culver, T. Durduran, T. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, "Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemia," J. Cereb. Blood Flow Metab. 23, 911-924 (2003). [CrossRef] [PubMed]
  24. T. Durduran, G. Yu, M. G. Burnett, J. A. Detre, J. H. Greenberg, J. Wang, C. Zhou, and A. G. Yodh, "Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation," Opt. Lett. 29, 1766-1768 (2004). [CrossRef] [PubMed]
  25. T. Durduran, R. Choe, G. Yu, C. Zhou, J. C. Tchou, B. J. Czerniecki, and A. G. Yodh, "Diffuse optical measurement of blood flow in breast tumors," Opt. Lett. 30, 2915-2917 (2005). [CrossRef] [PubMed]
  26. G. Q. Yu, T. Durduran, C. Zhou, H. Wang, M. E. Putt, H. M. Saunders, C. M. Sehgal, E. Glatstein, A. G. Yodh, and T. M. Busch, "Noninvasive monitoring of murine tumor blood flow during and after photodynamic therapy provides early assessment of therapeutic efficacy," Clin. Cancer Res. 11, 3543-3552 (2005). [CrossRef] [PubMed]
  27. J. Li, G. Dietsche, D. Iftime, S. E. Skipetrov, G. Maret, T. Elbert, B. Rockstroh, and T. Gisler, "Noninvasive detection of functional brain activity with near-infrared diffusing-wave spectroscopy," J. Biomed. Opt. 10(4), 044,002-1-12 (2005).
  28. C. Zhou, G. Yu, F. Daisuke, J. H. Greenberg, A. G. Yodh, and T. Durduran, "Diffuse optical correlation tomography of cerebral blood flow during cortical spreading depression in rat brain," Opt. Express 14, 1125-1144 (2006). [CrossRef] [PubMed]
  29. U. Sunar, H. Quon, T. Durduran, J. Zhang, J. Du, C. Zhou, G. Yu, R. Choe, A. Kilger, R. Lustig, L. Loevner, S. Nioka, B. Chance, and A. G. Yodh, "Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: a pilot study," J. Biomed. Opt. 11(6), 064,021-1-064,021-13 (2006).
  30. C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, "Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy," J. Biomed. Opt. 12(5), 051,903 (2007).
  31. F. Jaillon, J. Li, G. Dietsche, T. Elbert, and T. Gisler, "Activity of the human visual cortex measured noninvasively by diffusing-wave spectroscopy," Opt. Express 15(11), 6643-6650 (2007). [CrossRef]
  32. G. Yu, T. F. Floyd, T. Durduran, C. Zhou, J. Wang, J. A. Detre, and A. G. Yodh, "Validation of diffuse correlation spectroscopy for muscle blood flow with concurrent arterial spin labeled perfusion MRI," Opt. Express 15, 1064-1075 (2007). [CrossRef] [PubMed]
  33. J. Li, M. Ninck, L. Koban, T. Elbert, J. Kissler, and T. Gisler, "Transient functional blood flow change in the human brain measured noninvasively by diffusing-wave spectroscopy." Opt. Lett. 33(19), 2233-2235 (2008). [CrossRef]
  34. T. Durduran, C. Zhou, B. L. Edlow, G. Yu, R. Choe, M. N. Kim, B. L. Cucchiara, M. E. Putt, Q. Shah, S. E. Kasner, J. H. Greenberg, A. G. Yodh, and J. A. Detre, "Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients," Opt. Express 17(5), 3884-3902 (2009). [CrossRef]
  35. C. Zhou., S. Eucker, T. Durduran, G. Yu, S. Friess, R. Ichord, S. Margulies, and A. G. Yodh. "Diffuse optical monitoring of hemodynamics in piglet brain with head trauma injury," J. Biomed. Opt. (to be published).
  36. J. P. Finley, R. Hamilton, and M. G. MacKenzie, "Heart rate response to tilting in newborns in quiet and active sleep," Biol. Neonate 45(1), 1-10 (1984).
  37. H. Lagercrantz, D. Edwards, D. Hendersonsmart, T. Hertzberg, and H. Jeffery, "Autonomic reflexes in preterm infants," Acta Paediatr. Scand. 79, 721-728 (1990). [CrossRef] [PubMed]
  38. B. Urlesberger,W. Muller, E. Ritschl, and F. Reiterer, "The influence of head position on the intracranial-pressure in preterm infants with posthemorrhagic hydrocephalus," Childs Nervous System 7(2), 85-87 (1991).
  39. H. D. Dellagrammaticas, J. Kapetanakis, M. Papadimitriou, and G. Kourakis, "Effect of body tilting on physiological functions in stable very low birthweight neonates," Arch. Dis. Child. 66(4), 429-432 (1991). [CrossRef]
  40. R. Panerai, A. Wilfred, R. Kelsall, J. Rennie, and D. Evans, "Cerebral autoregulation dynamics in premature Newborns," Stroke 26, 74-80 (1995). [CrossRef] [PubMed]
  41. J. Gronlund, J. Jalonen, and I. Valimaki, "Transcephalic electrical impedance provides a means for quantifying pulsatile cerebral blood volume changes following head-up tilt," Early Hum. Dev. 47, 11-18 (1997). [CrossRef] [PubMed]
  42. G. Pichler, M. C. van Boetzelar, W. M¨uller, and B. Urlesberger "Effect of tilting on cerebral hemodynamics in preterm and term infants,"Biol. Neonate 80(3), 179-185 (2001). [CrossRef]
  43. L. Schrod, and J. Walter, "Effect of head-up body tilt position on autonomic function and cerebral oxygenation in preterm infants," Biol. Neonate 81(4), 255-259 (2002). [CrossRef]
  44. G. Pichler, B. Urlesberger, G. Schmolzer, W. Muller, "Effect of tilting on cerebral haemodynamics in preterm infants with periventricular leucencephalomalacia," Acta Paediatr. 93(1), 70-75 (2004).
  45. W. Brown, ed., Dynamic Light Scattering: The Method and Some Applications (Oxford University Press, 1993).
  46. L. Gagnon, M. Desjardins, J. Jehanne-Lacasse, L. Bherer, and F. Lesage, "Investigation of diffuse correlation spectroscopy in multi-layered media including the human head," Opt. Express 16(20), 15514-15530 (2008). [CrossRef]
  47. J. Hebden and T. Austin, "Optical tomography of the neonatal brain," European Radiology 17(11), 2926-2933 (2007). [CrossRef]
  48. J. C. Hebden, A. Gibson, R. Md Yusof, N. Everdell, E. M. C. Hillman, D. T. Delpy, S. R. Arridge, T. Austin, J. H. Meek, and J. S. Wyatt, "Three-dimensional optical tomography of the premature infant brain," Phys. Med. Biol. 47(23), 4155-4166 (2002). [CrossRef]
  49. C. Spearman, "The proof and measurement of association between two things. By C. Spearman, 1904." Am. J. Psychol. 100(3-4), 441-471 (1987). [CrossRef]
  50. F. Wilcoxon, "Individual Comparisons by Ranking Methods", Biometrics Bulletin 1(6), 80-83 (1945). [CrossRef]
  51. R Development Core Team (2008). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. ISBN 3-900051-07-0, URL http://www.R-project.org.
  52. Y. Hochberg, "A sharper Bonferroni procedure for multiple tests of significance" Biometrika 75, 800-802 (1988). [CrossRef]
  53. S. Ijichi, T. Kusaka, K. Isobe, K. Okubo, K. Kawada, M. Namba, H. Okada, T. Nishida, T. Imai, and S. Itoh, "Developmental Changes of Optical Properties in Neonates Determined by Near-Infrared Time-Resolved Spectroscopy," Pediatr. Res. 58(3), 568-573 (2005). [CrossRef]
  54. J. Zhao, H. S. Ding, X. L. Hou, C. L. Zhou, and B. Chance, "In vivo determination of the optical properties of infant brain using frequency-domain near-infrared spectroscopy," J. Biomed. Opt. 10(2), 024028-1-024028-7 (2005)

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