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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 17, Iss. 15 — Jul. 20, 2009
  • pp: 13157–13167

Analyzing absorption and scattering spectra of micro-scale structures with spectroscopic optical coherence tomography

Ji Yi, Jianmin Gong, and Xu Li  »View Author Affiliations

Optics Express, Vol. 17, Issue 15, pp. 13157-13167 (2009)

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We demonstrate the feasibility of characterizing the absorption and scattering spectra of micron-scale structures in a turbid medium using a spectroscopic optical coherence tomography (SOCT) system with a bandwidth of 430–650nm. SOCT measurements are taken from phantoms composed of fluorescent microspheres. The absorption and scattering spectra are recovered with proper selections of spatial window width in the post processing step. Furthermore, we present an analysis using numerical OCT simulation based on full-wave solutions of the Maxwell’s Equation to elucidate the origination of the multiple peaks in the OCT image for a single microsphere. Finally, we demonstrate the possibility of identifying contrast agents concentrated in micron-sized scale in an SOCT image. Two different types of microspheres in gel phantom are discriminated in 3D volume based on their distinguished absorbent feature.

© 2009 Optical Society of America

OCIS Codes
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(290.1350) Scattering : Backscattering
(300.1030) Spectroscopy : Absorption

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: April 13, 2009
Revised Manuscript: June 22, 2009
Manuscript Accepted: July 10, 2009
Published: July 17, 2009

Virtual Issues
Vol. 4, Iss. 9 Virtual Journal for Biomedical Optics

Ji Yi, Jianmin Gong, and Xu Li, "Analyzing absorption and scattering spectra of micro-scale structures with spectroscopic optical coherence tomography," Opt. Express 17, 13157-13167 (2009)

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