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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 17, Iss. 17 — Aug. 17, 2009
  • pp: 14481–14494

A source reconstruction algorithm based on adaptive hp-FEM for bioluminescence tomography

Runqiang Han, Jimin Liang, Xiaochao Qu, Yanbin Hou, Nunu Ren, Jingjing Mao, and Jie Tian  »View Author Affiliations

Optics Express, Vol. 17, Issue 17, pp. 14481-14494 (2009)

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As a novel modality of molecular imaging, bioluminescence tomography (BLT) is used to in vivo observe and measure the biological process at cellular and molecular level in small animals. The core issue of BLT is to determine the distribution of internal bioluminescent sources from optical measurements on external surface. In this paper, a new algorithm is presented for BLT source reconstruction based on adaptive hp-finite element method. Using adaptive mesh refinement strategy and intelligent permissible source region, we can obtain more accurate information about the location and density of sources, with the robustness, stability and efficiency improved. Numerical simulations and physical experiment were both conducted to verify the performance of the proposed algorithm, where the optical data on phantom surface were obtained via Monte Carlo simulation and CCD camera detection, respectively. The results represent the merits and potential of our algorithm for BLT source reconstruction.

© 2009 OSA

OCIS Codes
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.6280) Medical optics and biotechnology : Spectroscopy, fluorescence and luminescence
(170.6960) Medical optics and biotechnology : Tomography

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: May 26, 2009
Revised Manuscript: July 17, 2009
Manuscript Accepted: July 22, 2009
Published: August 3, 2009

Virtual Issues
Vol. 4, Iss. 10 Virtual Journal for Biomedical Optics

Runqiang Han, Jimin Liang, Xiaochao Qu, Yanbin Hou, Nunu Ren, Jingjing Mao, and Jie Tian, "A source reconstruction algorithm based on adaptive hp-FEM for bioluminescence tomography," Opt. Express 17, 14481-14494 (2009)

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