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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 17, Iss. 17 — Aug. 17, 2009
  • pp: 14694–14699

High-Q polymer-coated microspheres for immunosensing applications

S. Soria, F. Baldini, S. Berneschi, F. Cosi, A. Giannetti, G. Nunzi Conti, S. Pelli, G.C. Righini, and B. Tiribilli  »View Author Affiliations

Optics Express, Vol. 17, Issue 17, pp. 14694-14699 (2009)

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Homogeneous polymeric thin layers have been used as functionalizing agents on silica microspherical resonators in view of the implementation of an immunosensor. We have characterized the microspheres functionalised with poly-L-lactic acid and Eudragit® L100, as an alternative to the commonly used 3-Aminopropyltrimethoxysilane. It is shown that polymeric functionalization does not affect the high quality factor (Q greater than 107) of the silica microspheres, and that the Q factor is about 3x105 after chemical activation and covalent binding of immunogammaglobulin (IgG). This functionalizing process of the microresonator constitutes a promising step towards the achievement of an ultra sensitive immunosensor.

© 2009 OSA

OCIS Codes
(350.3950) Other areas of optics : Micro-optics
(280.4788) Remote sensing and sensors : Optical sensing and sensors

ToC Category:

Original Manuscript: June 8, 2009
Revised Manuscript: July 7, 2009
Manuscript Accepted: July 7, 2009
Published: August 4, 2009

Virtual Issues
Vol. 4, Iss. 10 Virtual Journal for Biomedical Optics

S. Soria, F. Baldini, S. Berneschi, F. Cosi, A. Giannetti, G. Nunzi Conti, S. Pelli, G. C. Righini, and B. Tiribilli, "High-Q polymer-coated microspheres for immunosensing applications," Opt. Express 17, 14694-14699 (2009)

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