OSA's Digital Library

Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 17, Iss. 17 — Aug. 17, 2009
  • pp: 15342–15349

Nanodoublers as deep imaging markers for multi-photon microscopy

Jerome Extermann, Luigi Bonacina, Enrique Cuña, Christelle Kasparian, Yannick Mugnier, Thomas Feurer, and Jean-Pierre Wolf  »View Author Affiliations

Optics Express, Vol. 17, Issue 17, pp. 15342-15349 (2009)

View Full Text Article

Enhanced HTML    Acrobat PDF (553 KB)

Browse Journals / Lookup Meetings

Browse by Journal and Year


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools



We demonstrate the possibility to excite second-harmonic (SH) active Fe(IO3)3 nanocrystals with two distinct laser sources at 800 and 1550 nm, and we show, by a complementary experimental and numerical study, how the wavelength flexibility inherent to non-phase-matched SH nanoparticles can be efficiently exploited to increase imaging penetration depth of markers embedded in biological samples.

© 2009 Optical Society of America

OCIS Codes
(170.7050) Medical optics and biotechnology : Turbid media
(180.4315) Microscopy : Nonlinear microscopy
(310.6628) Thin films : Subwavelength structures, nanostructures

ToC Category:

Original Manuscript: June 2, 2009
Revised Manuscript: July 15, 2009
Manuscript Accepted: July 20, 2009
Published: August 14, 2009

Virtual Issues
Vol. 4, Iss. 10 Virtual Journal for Biomedical Optics

Jerome Extermann, Luigi Bonacina, Enrique Cuña, Christelle Kasparian, Yannick Mugnier, Thomas Feurer, and Jean-Pierre Wolf, "Nanodoublers as deep imaging markers for multi-photon microscopy," Opt. Express 17, 15342-15349 (2009)

Sort:  Author  |  Year  |  Journal  |  Reset  


  1. L. Le Xuan, S. Brasselet, F. Treussart, J. F. Roch, F. Marquier, D. Chauvat, S. Perruchas, C. Tard, and T. Gacoin, "Balanced homodyne detection of second-harmonic generation from isolated subwavelength emitters", Appl. Phys. Lett. 89, 121118 (2006). [CrossRef]
  2. Y. Pu, M. Centurion, and D. Psaltis, "Harmonic holography: a new holographic principle", Appl. Opt. 47, A103- A110 (2008). [CrossRef] [PubMed]
  3. J. Extermann, L. Bonacina, F. Courvoisier, D. Kiselev, Y. Mugnier, R. Le Dantec, C. Galez, and J. P. Wolf, "Nano- FROG: Frequency resolved optical gating by a nanometric object", Opt. Express 16, 10405-10411 (2008). [CrossRef] [PubMed]
  4. P. Wnuk, L. Le Xuan, A. Slablab, C. Tard, S. Perruchas, T. Gacoin, J. F. Roch, D. Chauvat, and C. Radzewicz, "Coherent nonlinear emission from a single KTP nanoparticle with broadband femtosecond pulses", Opt. Express 17, 4652-4658 (2009). [CrossRef] [PubMed]
  5. Y. Nakayama, P. J. Pauzauskie, A. Radenovic, R. M. Onorato, R. J. Saykally, J. Liphardt, and P. D. Yang, "Tunable nanowire nonlinear optical probe", Nature 447, 1098-U8 (2007). [CrossRef] [PubMed]
  6. L. Le Xuan, C. Zhou, A. Slablab, D. Chauvat, C. Tard, S. Perruchas, T. Gacoin, P. Villeval, and J. F. Roch, "Photostable second-harmonic generation from a single KTiOPO4 nanocrystal for nonlinear microscopy", Small 4, 1332-1336 (2008). [CrossRef] [PubMed]
  7. A. V. Kachynski, A. N. Kuzmin, M. Nyk, I. Roy, and P. N. Prasad, "Zinc oxide nanocrystals for nonresonant nonlinear optical microscopy in biology and medicine", J. Phys. Chem. C 112, 10721-10724 (2008). [CrossRef]
  8. C. L. Hsieh, R. Grange, Y. Pu, and D. Psaltis, "Three-dimensional harmonic holographic microcopy using nanoparticles as probes for cell imaging", Opt. Express 17, 2880-2891 (2009). [CrossRef] [PubMed]
  9. L. Bonacina, Y. Mugnier, F. Courvoisier, R. Le Dantec, J. Extermann, Y. Lambert, V. Boutou, C. Galez, and J. P. Wolf, "Polar Fe(IO3)3 nanocrystals as local probes for nonlinear microscopy", Appl. Phys. B - Lasers Opt. 87, 399-403 (2007). [CrossRef]
  10. C. Galez, Y. Mugnier, J. Bouillot, Y. Lambert, and R. Le Dantec, "Synthesis and characterisation of Fe(IO3)3 nanosized powder", J. Alloys Comp. 416, 261-264 (2006). [CrossRef]
  11. V. Le Floc’h, S. Brasselet, J. F. Roch, and J. Zyss, "Monitoring of orientation in molecular ensembles by polarization sensitive nonlinear microscopy", J. Phys. Chem. B 107, 12403-12410 (2003). [CrossRef]
  12. J. Extermann, P. Bejot, L. Bonacina, Y. Mugnier, R. Le Dantec, T. Mazingue, C. Galez, and J. P. Wolf, "An inexpensive nonlinear medium for intense ultrabroadband pulse characterization", Appl. Phys. B - Lasers Opt. D.O.I. 10.1007/s00340-009-3569-x, (2009). [CrossRef]
  13. L. H. Wang, S. L. Jacques, and L.Q. Zheng, "Mcml - monte-carlo modeling of light transport in multilayered tissues", Computer Meth. Programs Biomed. 47, 131-146 (1995). [CrossRef]
  14. C. F. Bohren, and D. R. Huffmann, "Absorption and Scattering by Small Particles", Wiley Science paperback, (Wiley & Sons, New York, 1983).
  15. X. Y. Ma, J.Q. Lu, R. S. Brock, K. M. Jacobs, P. Yang, and X. H. Hu, "Determination of complex refractive index of polystyrene microspheres from 370 to 1610 nm", Phys. Med. Bio. 48, 4165-4172 (2003). [CrossRef]
  16. P. Parsa, S. L. Jacques, and N. S. Nishioka, "Optical-properties of rat-liver between 350 and 2200 nm", Appl. Opt. 28, 2325-2330 (1989). [CrossRef] [PubMed]
  17. B. B. Das, F. Liu, and R. R. Alfano, "Time-resolved fluorescence and photon migration studies in biomedical and model random media", Rep. Prog. Phys. 60, 227-292 (1997). [CrossRef]
  18. A. Volkmer, L. D. Book, and X. S. Xie, "Time-resolved coherent anti-stokes raman scattering microscopy: Imaging based on raman free induction decay", Appl. Phys. Lett. 80, 1505-1507 (2002). [CrossRef]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


Fig. 1. Fig. 2. Fig. 3.
Fig. 4.

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited