OSA's Digital Library

Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 17, Iss. 18 — Aug. 31, 2009
  • pp: 16291–16299

Assessment of photon migration in scattering media using heterodyning techniques with a frequency modulated diode laser

Zuguang Guan, Patrik Lundin, and Sune Svanberg  »View Author Affiliations


Optics Express, Vol. 17, Issue 18, pp. 16291-16299 (2009)
http://dx.doi.org/10.1364/OE.17.016291


View Full Text Article

Enhanced HTML    Acrobat PDF (581 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

A novel technique for studying photon propagation in scattering media is proposed and demonstrated, as is believed, for the first time. Photons propagating through the medium, from a frequency-ramped single-mode diode laser, meet a reference beam from the same source, at a common detector, and beat frequencies corresponding to various temporal delays are observed by heterodyne techniques. Fourier transformation directly yields the temporal dispersion curve. Proof-of-principle experiments on polystyrene foam and a tissue phantom suggest, that the new method, when fully developed, may favorably compete with the more complex time-correlated single-photon counting (TCSPC) and the phase-shift methods, now much employed.

© 2009 Optical Society of America

OCIS Codes
(120.0280) Instrumentation, measurement, and metrology : Remote sensing and sensors
(120.5820) Instrumentation, measurement, and metrology : Scattering measurements
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.6920) Medical optics and biotechnology : Time-resolved imaging

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: June 1, 2009
Revised Manuscript: July 17, 2009
Manuscript Accepted: July 17, 2009
Published: August 28, 2009

Virtual Issues
Vol. 4, Iss. 10 Virtual Journal for Biomedical Optics

Citation
Zuguang Guan, Patrik Lundin, and Sune Svanberg, "Assessment of photon migration in scattering media using heterodyning techniques with a frequency modulated diode laser," Opt. Express 17, 16291-16299 (2009)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-17-18-16291


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. B. Chance, J.S. Leigh, H. Miyake, D.S. Smith, S. Nioka, R. Greenfeld, M. Finander, K. Kaufmann, W. Levy, M. Young, P. Cohen, H. Yoshioka and R. Boretsky, "Comparison of time-resolved and -unresolved measurements of deoxyhemoglobin in the brain", Proc. Natl. Acad. Sci. USA 85, 4971 (1988). [CrossRef] [PubMed]
  2. S. Andersson-Engels, R. Berg, S. Svanberg and O. Jarlman, "Time-resolved transillumination for medical diagnostics", Opt. Lett. 15, 1179 (1990). [CrossRef] [PubMed]
  3. R. Berg, S. Andersson-Engels and S. Svanberg, "Time-resolved transillumination imaging", Optical Tomography, SPIE IS 11, 397 (1993).
  4. A. Taroni, A. Torricelli, L. Spinelli, A. Pifferi, F. Arpaia, G. Danesini and R. Cubeddu, "Time-resolved optical mammography between 637 and 985 nm: Clinical study on the detection and identification of breast lesions", Phys. Med. Biol. 50, 2469 (2005). [CrossRef] [PubMed]
  5. T. Svensson, S. Andersson-Engels, M. Einarsdóttír and K. Svanberg, "In vivo optical characterization of human prostate tissue using near-infrared time-resolved spectroscopy", J. Biomed. Opt. 12, 014022 (2007). [CrossRef] [PubMed]
  6. S. Andersson-Engels, R. Berg, A. Persson and S. Svanberg, "Multispectral tissue characterization using time-resolved detection of diffusely scattered white light", Opt. Lett. 18, 1697 (1993). [CrossRef] [PubMed]
  7. Ch. Abrahamsson, T. Svensson, S. Svanberg, S. Andersson-Engels, J. Johansson and S. Folestad, "Time and wavelength resolved spectroscopy of turbid media using light continuum generated in a crystal fibre", Opt. Exp. 12, 4103 (2004). [CrossRef]
  8. T. Fujii and T. Fukuchi (eds), Laser Remote Sensing (CRC Press, Boca Raton 2005).
  9. K. I. Aoyama, K. Nakagawa, and T. Itoh, "Optical-time domain reflectrometry in a single-mode fiber", IEEE J. Quant. Electr. 17, 862 (1981). [CrossRef]
  10. Z. G. Guan, M. Lewander, R. Grönlund, H. Lundberg and S. Svanberg, "Gas analysis in remote scattering targets using LIDAR techniques", Appl. Phys. B 93, 657 (2008). [CrossRef]
  11. M. Toida, T. Ichimura and H. Inaba, "The first demonstration of laser computed tomography achieved by coherent detection imaging method for biomedical applications", IEICE Trans. E 74, 1692 (1991).
  12. D. Uttam and B. Culshaw, "Precision time domain reflectometry in optical fiber systems using a frequency modulated continuous wave ranging technique", J. Lightwave Technol. LT- 3, 971 (1985). [CrossRef]
  13. W. V. Sorin, D. K. Donald, S. A. Newton and M. Nazarathy, "Coherent FMCW reflectometry using a temperature tuned Nd:YAG ring laser", IEEE Photonics Technol. Lett.,  2, 902 (1990). [CrossRef]
  14. C. J. Karlsson and F. Å. A. Olsson, "Linearization of the frequency sweep of a frequency-modulated continuous-wave semiconductor laser radar and the resulting ranging performance", Appl. Opt. 38, 3376 (1999). [CrossRef]
  15. S. R. Chinn and E. A. Swanson, "Optical coherence tomography using a frequency-tunable optical source", Opt. Lett. 22, 340 (1997). [CrossRef] [PubMed]
  16. K. Wårdell, A. Jakobsson and G. E. Nilsson, "Laser Doppler perfusion imaging by dynamic light scattering", IEEE Trans. Biomed. Eng.,  40, 309 (1993). [CrossRef] [PubMed]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

Figures

Fig. 1. Fig. 2. Fig. 3.
 
Fig. 4.
 

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited