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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 17, Iss. 19 — Sep. 14, 2009
  • pp: 16450–16455

Three-dimensional combined photoacoustic and optical coherence microscopy for in vivo microcirculation studies

Li Li, Konstantin Maslov, Geng Ku, and Lihong V. Wang  »View Author Affiliations

Optics Express, Vol. 17, Issue 19, pp. 16450-16455 (2009)

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Photoacoustic microscopy is predominantly sensitive to optical absorption, while optical coherence tomography relies on optical backscattering. Integrating their complementary contrasts can provide comprehensive information about biological tissue. We have developed a dual-modality microscope that combines the two for studying microcirculation. Three-dimensional imaging of microvasculature and its local environment has been demonstrated at micrometer-order resolution using endogenous contrast in vivo.

© 2009 OSA

OCIS Codes
(170.1870) Medical optics and biotechnology : Dermatology
(170.4470) Medical optics and biotechnology : Ophthalmology
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.5120) Medical optics and biotechnology : Photoacoustic imaging
(170.6900) Medical optics and biotechnology : Three-dimensional microscopy

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: July 2, 2009
Revised Manuscript: August 11, 2009
Manuscript Accepted: August 13, 2009
Published: August 31, 2009

Virtual Issues
Vol. 4, Iss. 11 Virtual Journal for Biomedical Optics

Li Li, Konstantin Maslov, Geng Ku, and Lihong V. Wang, "Three-dimensional combined photoacoustic and optical coherence microscopy for in vivo microcirculation studies," Opt. Express 17, 16450-16455 (2009)

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